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AB88519

Anti-GLUD2 antibody

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(1 Publication)

Mouse Polyclonal GLUD2 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GLUD2 aa 250 to C-terminus.

View Alternative Names

GLUDP1, GLUD2, GDH 2

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLUD2 antibody (AB88519)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLUD2 antibody (AB88519)

Immunoperoxidase staining of Human testis tissue using ab88519 at 3 μg/ml

Western blot - Anti-GLUD2 antibody (AB88519)
  • WB

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Western blot - Anti-GLUD2 antibody (AB88519)

All lanes:

Western blot - Anti-GLUD2 antibody (ab88519) at 1 µg/mL

All lanes:

Human kidney tissue lysate at 50 µg

Predicted band size: 61 kDa

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Western blot - Anti-GLUD2 antibody (AB88519)
  • WB

Unknown

Western blot - Anti-GLUD2 antibody (AB88519)

All lanes:

Western blot - Anti-GLUD2 antibody (ab88519) at 1 µg/mL

All lanes:

A431 cell lysate at 50 µg

Predicted band size: 61 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human GLUD2 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P49448

Specificity

Due to high sequence homology with GLUD1 there is a potential for cross-reactivity.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GLUD2 also known as glutamate dehydrogenase 2 plays a critical role in the conversion of glutamate to α-ketoglutarate and ammonia facilitated by the NAD+ or NADP+ cofactor. This enzyme belongs to the family of oxidoreductases and has a molecular mass of around 62 kDa. GLUD2 is mainly expressed in the brain specifically in neurons and glial cells reflecting its significant function in central nervous system activities.
Biological function summary

GLUD2 is involved in amino acid metabolism and neurotransmitter flux. It participates in balancing nitrogen and carbon important for neurotransmitter release and energy production in neural cells. The enzyme often exists as part of signaling complexes within mitochondria emphasizing its role in cellular energy homeostasis. Through its metabolic activities GLUD2 supports synapses in maintaining cognitive functions.

Pathways

GLUD2 plays important roles in the TCA cycle and glutamine-glutamate cycle. In the TCA cycle it facilitates the entry of nitrogen into the cycle via α-ketoglutarate production directly influencing cellular respiration and ATP generation. Its activity in the glutamine-glutamate cycle links it to interactions with glutaminase affecting synaptic signaling and plasticity which are vital for neural communication.

GLUD2 has associations with neurodegenerative conditions and metabolic disorders. Its malfunction contributes to hyperinsulinism-hyperammonemia syndrome and increased risk for certain neuropathologies like Alzheimer's disease. GLUD2's relationship with proteins like glutaminase and other dehydrogenases can influence the progression of these disorders by altering metabolic fluxes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
See full target information GLUD2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 16:1518481 PubMed39931687

2025

The gut-kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Cong Han,Ran-Ran Gao,Le Zhou,Wei Li
View all publications
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Product promise

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