Anti-GluK5 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GluK5 also called GluR7 or KA2 is a subunit of the kainate type of ionotropic glutamate receptors. It has a mass of about 112 kDa and is expressed mainly in the central nervous system especially in brain regions like the hippocampus and the cerebellum. This protein plays an important role as part of a receptor that governs excitatory neurotransmission by binding kainate a neurotransmitter analog.

Biological function summary

Kainate receptors including GluK5 contribute to synaptic plasticity and modulate synaptic transmission. GluK5 functions as part of a heteromeric complex typically with other GluK subunits like GluK1-4. Its presence influences excitatory postsynaptic currents and can also affect neurotransmitter release processes. This behavior impacts learning and memory making it an area of interest in neurophysiological studies.

Pathways

Kainate receptors participate in calcium signaling and glutamatergic synapse pathways. GluK5 interacts with other GluK subunits and proteins like PSD-95 which organizes receptor positioning at synapses. These pathways influence nerve signal propagation and synaptic strength connecting GluK5 to broader neuronal communication and plasticity mechanisms.

Associated diseases and disorders

Variations in GluK5 expression or function associate with neurological conditions such as temporal lobe epilepsy and schizophrenia. Studies suggest GluK5 subunit may impact glutamate signaling in these diseases. In epilepsy the imbalance in excitatory and inhibitory neurotransmission involving GluK5 may lead to seized activities. Additionally its connection with other receptors like NMDA in these disorders can complicate signaling pathways posing potential targets for therapeutic interventions.