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AB92743

Anti-GluN2D antibody

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Rabbit Polyclonal GluN2D antibody. Suitable for WB and reacts with African green monkey samples. Immunogen corresponding to Synthetic Peptide within Human GRIN2D.

View Alternative Names

GluN2D, NMDAR2D, GRIN2D, EB11, Glutamate [NMDA] receptor subunit epsilon-4, N-methyl D-aspartate receptor subtype 2D, NR2D

1 Images
Western blot - Anti-GluN2D antibody (AB92743)
  • WB

Unknown

Western blot - Anti-GluN2D antibody (AB92743)

All lanes:

Western blot - Anti-GluN2D antibody (ab92743) at 1/500 dilution

Lane 1:

COS7 cell extract at 10 µg

Lane 2:

COS7 cell extract at 10 µg with immunizing peptide

Predicted band size: 144 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

African green monkey

Applications

WB

applications

Immunogen

Synthetic Peptide within Human GRIN2D. The exact immunogen used to generate this antibody is proprietary information.

O15399

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Biochemicals

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "African green monkey": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GluN2D also known as GRIN2D or NR2D is a subunit of the NMDA (N-methyl-D-aspartate) receptor which plays an essential role in excitatory neurotransmission in the brain. It has a molecular mass of about 130 kDa. This protein is primarily expressed in the central nervous system including the neocortex hippocampus and thalamus. GluN2D's role within the NMDA receptor complex involves modulating synaptic plasticity learning and memory processes by binding with calcium ions.
Biological function summary

GluN2D contributes to the complexity of neuronal communication and signaling. It is an integral component of the NMDA receptor complex which is a heterotetramer consisting of GluN1 GluN2 and occasionally GluN3 subunits. The GluN2D subunit influences the receptor's biophysical and pharmacological properties affecting the duration and amplitude of the excitatory postsynaptic current. Through these functions GluN2D plays a role in synaptic transmission and neuroplasticity impacting how neurons adapt to various stimuli and experiences.

Pathways

GluN2D plays significant roles in synaptic signaling and neurodevelopmental pathways. In synaptic signaling GluN2D modulates calcium ion influx which is necessary for activating intracellular pathways involving proteins like CaMKII critical for long-term potentiation and memory formation. In development its involvement in neuronal differentiation and maturation interacts with proteins like PSD-95 which are essential for organizing synaptic architecture and function. These pathways highlight the functional importance of GluN2D in both synaptic and developmental contexts.

GluN2D is associated with neurological and psychiatric conditions such as epilepsy and schizophrenia. Variations in GRIN2D gene expression or function can disrupt NMDA receptor activity leading to an imbalance in excitatory and inhibitory neurotransmission in the central nervous system. This imbalance can contribute to seizure generation in epilepsy or the symptoms observed in schizophrenia. Additionally GluN2D interactions with proteins like DLG4 associated with postsynaptic density further influence these disease mechanisms offering potential therapeutic targets for intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed : 26875626, PubMed : 27616483, PubMed : 28126851, PubMed : 9489750). Participates in synaptic plasticity for learning and memory formation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed : 26875626, PubMed : 27616483, PubMed : 28126851, PubMed : 9489750). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed : 26875626, PubMed : 28095420, PubMed : 28126851, PubMed : 9489750).
See full target information GRIN2D
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