AB36057

Anti-GLUT5 antibody

Name: Anti-GLUT5 antibody (ab36057) | Abcam
Brand: Abcam Limited
SKU: AB36057
Price: 535 USD
Availability: InStock

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(10 Publications)

Rabbit Polyclonal GLUT5 antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human SLC2A5 aa 450-500 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

GLUT5, SLC2A5, Fructose transporter, GLUT-5

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, IHC-Fr, WB

applications

Immunogen

Synthetic Peptide within Human SLC2A5 aa 450-500 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P22732

Specificity

Does not react with GLUT1, 2, 3 or 4 from human, mouse or rat.

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Reactivity data

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Product details

Concentration is approximately 5 mg/ml.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GLUT5 also known as SLC2A5 is a fructose transporter protein that is part of the class II facilitative glucose transporter family. This protein has a molecular mass of approximately 58 kDa. It is highly expressed in the small intestine where it facilitates the uptake of dietary fructose into enterocytes. GLUT5 is also found in other tissues including the kidney testis skeletal muscle and fat tissue but at lower levels.

Biological function summary

GLUT5 plays a vital role in fructose metabolism and energy homeostasis. It functions as a carrier protein mediating the passive transport of fructose along its concentration gradient. GLUT5 does not form a complex with other transporters but works alongside them like GLUT2 which is responsible for fructose export from enterocytes into the bloodstream.

Pathways

GLUT5 is significantly involved in carbohydrate digestion and absorption pathways. It interacts with proteins like GLUT2 during the process of fructose transport across the intestinal epithelium. This functional interaction is key in maintaining normal blood sugar levels and ensuring efficient nutrient absorption post-digestion.

Improper function of GLUT5 relates to fructose malabsorption and metabolic conditions such as obesity. Fructose malabsorption can cause gastrointestinal distress and contribute to irritable bowel syndrome. Furthermore GLUT5 expression studies in obesity link it to other proteins like leptin which influences appetite and energy balance.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed : 16186102, PubMed : 17710649, PubMed : 28083649, PubMed : 29548810, PubMed : 8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed : 1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).

See full target information SLC2A5

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational internal medicine 12:367-383 PubMed39360156

2024

Recognition of differently expressed genes and DNA methylation markers in patients with Lupus nephritis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenjie Liu,Fengxun Liu,Junwei Xie,Zihao Zhao,Shaokang Pan,Dongwei Liu,Zongping Xia,Zhangsuo Liu

British journal of cancer 125:734-747 PubMed34188196

2021

S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Mingdao Lin,Yuan Fang,Zhenkang Li,Yongsheng Li,Xiaochuang Feng,Yizhi Zhan,Yuwen Xie,Yuechen Liu,Zehao Liu,Guoxin Li,Zhiyong Shen,Haijun Deng

Molecular therapy. Nucleic acids 25:11-24 PubMed34141461

2021

lncRNA GAS6-AS1 inhibits progression and glucose metabolism reprogramming in LUAD via repressing E2F1-mediated transcription of GLUT1.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Luo,Huishan Wang,Li Wang,Gaoming Wang,Yu Yao,Kai Xie,Xiaokun Li,Lin Xu,Yi Shen,Binhui Ren

Cell and tissue research 383:1103-1122 PubMed33159578

2020

Immunolocalization of leptin and leptin receptor in colorectal mucosa of ulcerative colitis, Crohn's disease and control subjects with no inflammatory bowel disease.

Applications

Unspecified application

Species

Unspecified reactive species

Flavia Merigo,Alessandro Brandolese,Sonia Facchin,Federico Boschi,Marzia Di Chio,Edoardo Savarino,Renata D'Incà,Giacomo Carlo Sturniolo,Andrea Sbarbati

OncoTargets and therapy 12:5425-5436 PubMed31371983

2019

GLUT5 increases fructose utilization in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Cuiping Jin,Xiaojin Gong,Yumin Shang

World journal of gastroenterology 24:775-793 PubMed29467549

2018

Glucose transporter expression in the human colon.

Applications

Unspecified application

Species

Unspecified reactive species

Flavia Merigo,Alessandro Brandolese,Sonia Facchin,Silvia Missaggia,Paolo Bernardi,Federico Boschi,Renata D'Incà,Edoardo Vincenzo Savarino,Andrea Sbarbati,Giacomo Carlo Sturniolo

PloS one 6:e26508 PubMed22073170

2011

An essential farnesylated kinesin in Trypanosoma brucei.

Applications

IHC-P

Species

Human

Erin J Engelson,Frederick S Buckner,Wesley C Van Voorhis

PloS one 6:e26902 PubMed22073218

2011

GLUT 5 is not over-expressed in breast cancer cells and patient breast cancer tissues.

Applications

IHC-P

Species

Human

Gayatri Gowrishankar,Sabine Zitzmann-Kolbe,Anitha Junutula,Robert Reeves,Jelena Levi,Ananth Srinivasan,Kjerstin Bruus-Jensen,John Cyr,Ludger Dinkelborg,Sanjiv S Gambhir

Critical care (London, England) 15:R131 PubMed21612615

2011

Hyperglycaemia and apoptosis of microglial cells in human septic shock.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Polito,Jean-Philippe Brouland,Raphael Porcher,Romain Sonneville,Shidasp Siami,Robert D Stevens,Céline Guidoux,Virginie Maxime,Geoffroy Lorin de la Grandmaison,Fabrice C Chrétien,Françoise Gray,Djillali Annane,Tarek Sharshar

Oncology reports 25:315-23 PubMed21165569

2010

Fructose transporter GLUT5 expression in clear renal cell carcinoma.

Applications

IHC-P

Species

Human

V Medina Villaamil,G Aparicio Gallego,L Valbuena Rubira,R García Campelo,M Valladares-Ayerbes,E Grande Pulido,M Victoria Bolós,I Santamarina Caínzos,L M Antón Aparicio

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GLUT5 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (10)

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