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AB41533

Anti-GLUT5 antibody

1

(1 Review)

|

(5 Publications)

Rabbit Polyclonal GLUT5 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SLC2A5.

View Alternative Names

GLUT5, SLC2A5, Fructose transporter, GLUT-5

1 Images
Western blot - Anti-GLUT5 antibody (AB41533)
  • WB

Unknown

Western blot - Anti-GLUT5 antibody (AB41533)

All lanes:

Western blot - Anti-GLUT5 antibody (ab41533) at 1 µg/mL

All lanes:

Human small intestine tissue lysate - total protein (<a href='/en-us/products/unavailable/human-small-intestine-tissue-lysate-total-protein-ab29276'>ab29276</a>) at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution

Predicted band size: 55 kDa

Observed band size: 25 kDa,55 kDa,71 kDa

true

Exposure time: 20min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SLC2A5. The exact immunogen used to generate this antibody is proprietary information.

P22732

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Isolated on antigen-sepharose affinity column.
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GLUT5 also known as SLC2A5 is a fructose transporter protein that is part of the class II facilitative glucose transporter family. This protein has a molecular mass of approximately 58 kDa. It is highly expressed in the small intestine where it facilitates the uptake of dietary fructose into enterocytes. GLUT5 is also found in other tissues including the kidney testis skeletal muscle and fat tissue but at lower levels.
Biological function summary

GLUT5 plays a vital role in fructose metabolism and energy homeostasis. It functions as a carrier protein mediating the passive transport of fructose along its concentration gradient. GLUT5 does not form a complex with other transporters but works alongside them like GLUT2 which is responsible for fructose export from enterocytes into the bloodstream.

Pathways

GLUT5 is significantly involved in carbohydrate digestion and absorption pathways. It interacts with proteins like GLUT2 during the process of fructose transport across the intestinal epithelium. This functional interaction is key in maintaining normal blood sugar levels and ensuring efficient nutrient absorption post-digestion.

Improper function of GLUT5 relates to fructose malabsorption and metabolic conditions such as obesity. Fructose malabsorption can cause gastrointestinal distress and contribute to irritable bowel syndrome. Furthermore GLUT5 expression studies in obesity link it to other proteins like leptin which influences appetite and energy balance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed : 16186102, PubMed : 17710649, PubMed : 28083649, PubMed : 29548810, PubMed : 8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed : 1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
See full target information SLC2A5
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

The FEBS journal 290:4480-4495 PubMed37171230

2023

Metformin exerts antileukemic effects by modulating lactate metabolism and overcomes imatinib resistance in chronic myelogenous leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Meher Bolisetti Gayatri,Rama Krishna Kancha,Dorababu Patchva,Nagaraj Velugonda,Sadashivudu Gundeti,Aramati B M Reddy

Nature communications 12:1209 PubMed33619282

2021

Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Nicholas Jones,Julianna Blagih,Fabio Zani,April Rees,David G Hill,Benjamin J Jenkins,Caroline J Bull,Diana Moreira,Azari I M Bantan,James G Cronin,Daniele Avancini,Gareth W Jones,David K Finlay,Karen H Vousden,Emma E Vincent,Catherine A Thornton

Antioxidants & redox signaling 22:848-70 PubMed25602171

2015

Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation.

Applications

Unspecified application

Species

Unspecified reactive species

Xian Zhang,Jian-Hua Zhang,Xu-Yang Chen,Qing-Hua Hu,Ming-Xing Wang,Rui Jin,Qing-Yu Zhang,Wei Wang,Rong Wang,Lin-Lin Kang,Jin-Sheng Li,Meng Li,Ying Pan,Jun-Jian Huang,Ling-Dong Kong

PloS one 8:e67771 PubMed23861803

2013

Neuroprotective activity of peripherally administered liver growth factor in a rat model of Parkinson's disease.

Applications

WB

Species

Unspecified reactive species

Rafael Gonzalo-Gobernado,Lucía Calatrava-Ferreras,Diana Reimers,Antonio Sánchez Herranz,Macarena Rodríguez-Serrano,Cristina Miranda,Adriano Jiménez-Escrig,Juan José Díaz-Gil,Eulalia Bazán

PloS one 6:e25204 PubMed21980397

2011

Fructose modulates cardiomyocyte excitation-contraction coupling and Ca²⁺ handling in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Kimberley M Mellor,James R Bell,Igor R Wendt,Amy J Davidoff,Rebecca H Ritchie,Lea M D Delbridge
View all publications
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Product promise

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