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AB201172

Anti-Glutaminyl cyclase antibody

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(6 Publications)

Rabbit Polyclonal Glutaminyl cyclase antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Glutaminyl-peptide cyclotransferase aa 150-350.

View Alternative Names

Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, Glutaminyl-tRNA cyclotransferase, Glutamyl cyclase, QC, sQC, EC, QPCT

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutaminyl cyclase antibody (AB201172)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutaminyl cyclase antibody (AB201172)

Immunohistochemical analysis of formalin fixed, paraffin embedded human thyroid tissue labeling Glutaminyl cyclase with ab201172 at a 1/100 dilution.

Western blot - Anti-Glutaminyl cyclase antibody (AB201172)
  • WB

Supplier Data

Western blot - Anti-Glutaminyl cyclase antibody (AB201172)

All lanes:

Western blot - Anti-Glutaminyl cyclase antibody (ab201172) at 1/500 dilution

Lane 1:

HepG2 cell line lysate

Lane 2:

Jurkat cell line lysate

Predicted band size: 41 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Glutaminyl-peptide cyclotransferase aa 150-350. The exact immunogen used to generate this antibody is proprietary information.

Q16769

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glutaminyl cyclase also known by the alternate name 'QC' catalyzes the conversion of glutaminyl residues towards pyroglutamyl formation in proteins. This enzyme weighs around 39 kDa and is distributed across various tissues with significant expression in the brain and secretory tissues. The active site of this enzyme facilitates the cyclization of N-terminal glutaminyl and glutamyl residues influencing protein stability and function.
Biological function summary

This enzyme modifies peptide hormones and neuropeptides by enhancing their activity or stability. Glutaminyl cyclase does not usually operate within large protein complexes. However its activity is critical for processing secretory proteins into their mature forms. Modifications by the enzyme often regulate peptide function making it an important player in cellular communication processes.

Pathways

Glutaminyl cyclase plays an important role in the neuroendocrine cascade and protein maturation pathways. This enzyme's activity connects with other proteins like hormone receptors affecting their downstream signaling processes. It also shares connections with proteins involved in the proteolytic processing pathway ensuring maturation and activation of peptide substrates.

Malfunction of glutaminyl cyclase associates with Alzheimer's disease and amyloidosis. The enzyme's activity influences accumulation of pyroglutamyl-modified proteins which have links to amyloid plaque formation in Alzheimer's disease. This connection involves amyloid-beta peptides where glutaminyl cyclase enhances the aggregation potential through N-terminal cyclization. Effective modulation of this enzyme’s activity might represent a therapeutic approach for related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
See full target information Glutaminyl-peptide cyclotransferase
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

PloS one 19:e0312773 PubMed39531472

2024

Increased QPCT gene expression by the hepatitis B virus promotes HBV replication.

Applications

Unspecified application

Species

Unspecified reactive species

Conghui Zhang,Qingfeng Ma,Wei Wang,Hui Song,Xue Wang,Fengxia Xu,Chengliang Zhu,Xinghui Liu

Mediators of inflammation 2024:9986187 PubMed38716374

2024

Potential Association of Gut Microbial Metabolism and Circulating mRNA Based on Multiomics Sequencing Analysis in Fetal Growth Restriction.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Tang,Dan Li,Jing Peng,Weitao Yang,Xian Zhang,Hanmei Li

The Journal of surgical research 276:404-415 PubMed35468367

2022

Effects of Multi-stage Procurement on the Viability and Function of Human Donor Parathyroid Glands.

Applications

Unspecified application

Species

Unspecified reactive species

Yvonne M Kelly,Casey Ward,Run Zhang,Shareef Syed,Peter G Stock,Quan-Yang Duh,Julie A Sosa,James Koh

International journal of oncology 59: PubMed34036385

2021

QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Tangliang Zhao,Yulin Zhou,Qingyun Wang,Xiaoming Yi,Silun Ge,Haowei He,Song Xue,Bowen Du,Jingping Ge,Jie Dong,Le Qu,Linhui Wang,Wenquan Zhou

Theranostics 9:6175-6190 PubMed31534544

2019

DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tangliang Zhao,Yi Bao,Xinxin Gan,Jie Wang,Qiong Chen,Zhihui Dai,Bing Liu,Anbang Wang,Shuhan Sun,Fu Yang,Linhui Wang

International immunopharmacology 75:105770 PubMed31377588

2019

Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojuan Wang,Li Wang,Xi Yu,Yue Li,Zhigang Liu,Yongdong Zou,Yizhi Zheng,Zhendan He,Haiqiang Wu
View all publications
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Product promise

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