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AB187859

Anti-GLYATL1 antibody

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(2 Publications)

Rabbit Polyclonal GLYATL1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GLYATL1 aa 100-200.

View Alternative Names

GNAT, GLYATL1, Glycine N-acyltransferase-like protein 1, Acyl-CoA:glycine N-acyltransferase-like protein 1, Glutamine N-acyltransferase

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLYATL1 antibody (AB187859)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLYATL1 antibody (AB187859)

Immunohistochemical analysis of paraffin-embedded Human kidney tissue labeling GLYALT1 with ab187859 at 1/500 dilution.

Western blot - Anti-GLYATL1 antibody (AB187859)
  • WB

Supplier Data

Western blot - Anti-GLYATL1 antibody (AB187859)

All lanes:

Western blot - Anti-GLYATL1 antibody (ab187859) at 1/100 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U-251MG sp cell lysate

Lane 3:

Human plasma (IgG/HSA depleted) lysate

Lane 4:

Human liver tissue lysate

Predicted band size: 35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human GLYATL1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q969I3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein GLYATL1 also known as Glycine-N-acyltransferase-like 1 functions as an acyltransferase enzyme. Mechanically GLYATL1 facilitates the transfer of acyl groups to glycine. It displays a molecular weight of approximately 27 kDa. The expression of GLYATL1 is found in the liver and to some extent in the kidney serving an important function related to detoxification processes.
Biological function summary

The enzymatic action of GLYATL1 aids in the detoxification of metabolites by conjugating them to amino acids primarily glycine. It appears to function independently and is not known to form part of larger protein complexes. Its activity contributes to the reduction of potential toxicity from a variety of substrates helping to neutralize harmful compounds.

Pathways

Enzyme GLYATL1 plays a major role within the amino acid conjugation pathway which is part of phase II drug metabolism. It functions in concert with other detoxifying enzymes such as glycine N-acyltransferase (GLYAT) to bolster the liver's ability to process and eliminate xenobiotics. This pathway is critical for converting lipophilic substances into water-soluble products that can be excreted from the body.

Aberrant GLYATL1 activity is linked to conditions affecting the liver such as hepatic injury or dysfunction. Altered expression or function may contribute to insufficient detoxification leading to an accumulation of toxic compounds. Additionally its regulatory function in metabolite conjugation can also intersect with metabolic disorders that affect amino acid processing.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.
See full target information GLYATL1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 11: PubMed36672708

2023

Comparing the Biology of Young versus Old Age Estrogen-Receptor-Positive Breast Cancer through Gene and Protein Expression Analyses.

Applications

Unspecified application

Species

Unspecified reactive species

Alaa Siddig,Wan Faiziah Wan Abdul Rahman,Siti Norasikin Mohd Nafi,Sarina Sulong,Maya Mazuwin Yahya,Tengku Ahmad Damitri Al-Astani Tengku Din,Rozaimi Razali,Kamarul Imran Musa

American journal of translational research 13:10075-10093 PubMed34650682

2021

HNSC exosome-derived MIAT improves cognitive disorders in rats with vascular dementia the miR-34b-5p/CALB1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Qi,Xiaojun Hou,Chunfeng Jin,Xi Chen,Chengli Pan,Hongjuan Fu,Leifeng Song,Jujun Xue
View all publications
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Product promise

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