JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB272606

Anti-Glycogenin 1 antibody

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Polyclonal Glycogenin 1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GYG1 aa 200 to C-terminus.

View Alternative Names

GYG, GYG1, Glycogenin-1, GN-1, GN1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Glycogenin 1 antibody (AB272606)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Glycogenin 1 antibody (AB272606)

PFA fixed, Triton X-100 permeablized human cell line U-251 MG labeling Glycogenin 1 (green) using ab272606at 2 ug/ml in ICC/IF analysis.

Western blot - Anti-Glycogenin 1 antibody (AB272606)
  • WB

Supplier Data

Western blot - Anti-Glycogenin 1 antibody (AB272606)

All lanes:

Western blot - Anti-Glycogenin 1 antibody (ab272606) at 0.4 µg/mL

All lanes:

Human testis tissue lysate

Predicted band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human GYG1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P46976

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glycogenin 1 also known as GYG1 plays an essential role in the initiation of glycogen biosynthesis. This protein acts as a primer that starts glycogen formation by autoglucosylation attaching glucose residues to itself which leads to the formation of a glycogen molecule. With a molecular mass of approximately 37 kDa Glycogenin 1 is expressed widely in tissues showing high levels in skeletal muscle heart and liver. It forms a homodimer and possesses conserved surface residues necessary for its enzymatic function.
Biological function summary

Glycogenin 1 serves as the foundation for glycogen granule formation by providing the initial glucose chain that glycogen synthase can extend. The protein participates in the formation of a macromolecular complex that includes glycogen synthase and glycogen branching enzyme facilitating efficient glycogen deposition. The association with these enzymes ensures that the glycogen is structured properly optimizing cellular energy storage. Glycogenin 1 acts as the core around which all further glucose additions are built making it indispensable for maintaining energy reserves.

Pathways

Glycogenin 1 is integral to glycogen metabolism. It plays a critical role within the glycogen biosynthesis pathway closely interacting with proteins such as glycogen synthase and the branching enzyme. The coordinated activity of Glycogenin 1 glycogen synthase and the branching enzyme is necessary for the proper assembly of glycogen particles. This pathway regulation impacts glucose homeostasis and energy management in muscle and liver tissues indicating its importance for metabolic balance.

Mutations or dysfunctions in Glycogenin 1 link to glycogen storage diseases such as Glycogen Storage Disease Type XV (GSD XV). This disorder arises when an abnormal Glycogenin 1 fails to synthesize the primer glucose molecules leading to energy storage issues. The disease symptoms often resemble those seen with impaired glycogen synthase function as both proteins are involved in glycogen accumulation. Efficient glycogen synthesis disruptions highlight Glycogenin 1's therapeutic research importance in metabolic diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
See full target information GYG1
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB236179

Recombinant Human Wnt4 protein (Tagged)

SDS-PAGE - Recombinant Human Wnt4 protein (Tagged) (AB236179)

  • 0
  • 0
Proteins & Peptides

AB87624

Recombinant Human Glycogenin 1 protein

SDS-PAGE - Recombinant Human Glycogenin 1 protein (AB87624)

  • 0
  • 0
Proteins & Peptides

AB78710

Recombinant Human 14-3-3 eta/YWHAH protein

SDS-PAGE - Recombinant Human 14-3-3 eta/YWHAH protein (AB78710)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com