Anti-Glycophorin C/GPC antibody
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(2 Publications )
Rabbit Polyclonal Glycophorin C/GPC antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GYPC.
View Alternative Names
CD236, GLPC, GPC, GYPC, Glycophorin-C, Glycoconnectin, Glycophorin-D, Glycoprotein beta, PAS-2', Sialoglycoprotein D, GPD
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glycophorin C/GPC antibody (AB175257)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human esophageal cancer tissue labelling GYPC with ab175257 at 1/200. Magnification : 200x.
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-Glycophorin C/GPC antibody (AB175257)
Immunocytochemistry/Immunofluorescence analysis of MCF7 cells using ab175257. Blue DAPI for nuclear staining.
- WB
Supplier Data
Western blot - Anti-Glycophorin C/GPC antibody (AB175257)
All lanes:
Western blot - Anti-Glycophorin C/GPC antibody (ab175257) at 1/500 dilution
Lane 1:
TF-1 cell line lysate
Lane 2:
K562 cell line lysate
Lane 3:
Red blood cells
Predicted band size: 14 kDa
false
Reactivity data
Properties and storage information
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Purification technique
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Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Glycophorin C modulates red blood cell characteristics by interacting with band 4.1 protein complex. The protein participates in the regulation of cell shape and mechanical flexibility which are important for the red blood cells to flow through capillaries effectively. This process involves interactions with spectrin and actin within the cytoskeleton underpinning the cellular architecture. The protein's function as an anchor for the band 4.1 complex links it with other glycophorins such as Glycophorin A.
Pathways
GPC integrates into erythrocyte membrane-associated pathways supporting membrane stability. It is key to the cytoskeleton-membrane linkage pathway where it interacts with proteins like spectrin and actin. Aimed at preserving the biconcave shape of erythrocytes these interactions enhance membrane elasticity and durability ensuring proper red blood cell function in the circulation. Additionally its association with the protein Rh-linked ankyrin connects GPC with pathways involving erythrocyte ion transport processes.
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Target data
Publications (2)
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Scientific reports 13:12309 PubMed37516749
2023
Applications
Unspecified application
Species
Unspecified reactive species
Nature communications 11:4015 PubMed32782246
2020
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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