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AB108619

Anti-Glycophorin C/GPC antibody [EPR4115]

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(3 Publications)

Rabbit Recombinant Monoclonal Glycophorin C/GPC antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

CD236, GLPC, GPC, GYPC, Glycophorin-C, Glycoconnectin, Glycophorin-D, Glycoprotein beta, PAS-2', Sialoglycoprotein D, GPD

1 Images
Western blot - Anti-Glycophorin C/GPC antibody [EPR4115] (AB108619)
  • WB

Unknown

Western blot - Anti-Glycophorin C/GPC antibody [EPR4115] (AB108619)

All lanes:

Western blot - Anti-Glycophorin C/GPC antibody [EPR4115] (ab108619) at 1/1000 dilution

Lane 1:

TF1 cell lysates at 10 µg

Lane 2:

K562 cell lysates at 10 µg

Predicted band size: 14 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR4115

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glycophorin C also known as GPC is a membrane glycoprotein with a molecular mass of approximately 32 kDa. GPC is recognized by other names such as Glycophorin A-like and it is a significant component of the erythrocyte membrane. Researchers frequently refer to glycophorin C by its common abbreviation GPC. GPC expression occurs specifically in red blood cells where it plays a role in maintaining the cell structure and integrity by forming part of the interface between the cell membrane and the cytoskeleton.
Biological function summary

Glycophorin C modulates red blood cell characteristics by interacting with band 4.1 protein complex. The protein participates in the regulation of cell shape and mechanical flexibility which are important for the red blood cells to flow through capillaries effectively. This process involves interactions with spectrin and actin within the cytoskeleton underpinning the cellular architecture. The protein's function as an anchor for the band 4.1 complex links it with other glycophorins such as Glycophorin A.

Pathways

GPC integrates into erythrocyte membrane-associated pathways supporting membrane stability. It is key to the cytoskeleton-membrane linkage pathway where it interacts with proteins like spectrin and actin. Aimed at preserving the biconcave shape of erythrocytes these interactions enhance membrane elasticity and durability ensuring proper red blood cell function in the circulation. Additionally its association with the protein Rh-linked ankyrin connects GPC with pathways involving erythrocyte ion transport processes.

GPC plays a notable role in elliptocytosis and malaria. Elliptocytosis arises from mutations affecting GPC and other erythrocyte proteins such as band 4.1 leading to elongated and dysfunctional erythrocytes. Individuals with altered GPC expression show increased susceptibility or resistance to malaria caused by the Plasmodium parasite’s interaction with erythrocyte membrane proteins. Glycophorin C therefore remains an important focus of study for understanding the molecular basis of these conditions and designing therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
See full target information GYPC
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:6801 PubMed36357417

2022

Wireless theranostic smart contact lens for monitoring and control of intraocular pressure in glaucoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tae Yeon Kim,Jee Won Mok,Sang Hoon Hong,Sang Hoon Jeong,Hyunsik Choi,Sangbaie Shin,Choun-Ki Joo,Sei Kwang Hahn

Journal of translational medicine 18:313 PubMed32795291

2020

Identification and validation of smoking-related genes in lung adenocarcinoma using an in vitro carcinogenesis model and bioinformatics analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Wang,Tao Chen,Xiaofan Yu,Nan OUYang,Lirong Tan,Beibei Jia,Jian Tong,Jianxiang Li

British journal of haematology 168:429-42 PubMed25283956

2014

Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation.

Applications

Unspecified application

Species

Unspecified reactive species

Perry Maxwell,Florinda Melendez-Rodríguez,Kyle B Matchett,Julian Aragones,Nathalie Ben-Califa,Heidelinde Jaekel,Ludger Hengst,Herbert Lindner,Andre Bernardini,Ulf Brockmeier,Joachim Fandrey,Fritz Grunert,Howard S Oster,Moshe Mittelman,Mohamed El-Tanani,Markus Thiersch,Edith M Schneider Gasser,Max Gassmann,David Dangoor,Robert J Cuthbert,Alexandra Irvine,Anne Jordan,Terence Lappin,John Thompson,Drorit Neumann
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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