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AB9667

Anti-GM-CSF antibody

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(3 Publications)

Rabbit Polyclonal GM-CSF antibody. Carrier free. Suitable for sELISA and reacts with Recombinant full length protein - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CSF2.

View Alternative Names

GMCSF, CSF2, Granulocyte-macrophage colony-stimulating factor, GM-CSF, Colony-stimulating factor, Molgramostin, Sargramostim, CSF

1 Images
Sandwich ELISA - Anti-GM-CSF antibody (AB9667)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-GM-CSF antibody (AB9667)

Sandwich ELISA of ab9667. Allows the detection of 0.2 - 0.4 ng/well of recombinant hGM-CSF (using 100μl/well antibody solution). Can be paired for Sandwich ELISA with ab84259. Can be used as the capture antibody when paired with recommended pair.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Applications

sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CSF2.

P04141

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "0.5-2 µg/mL", "sELISA-species-notes": "<p>Allows the detection of 0.2 - 0.4 ng/well of recombinant hGM-CSF (using 100μl/well antibody solution). Can be paired for Sandwich ELISA with <a href='/en-us/products/primary-antibodies/biotin-gm-csf-antibody-ab84259'>ab84259</a>. Can be used as the capture antibody when paired with recommended pair.</p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GM-CSF also known as Granulocyte-Macrophage Colony-Stimulating Factor is a glycoprotein with a mass of approximately 23 kDa. This protein plays a mechanical role in stimulating the differentiation and proliferation of hematopoietic progenitor cells into granulocytes and macrophages. Its expression occurs in various cell types including macrophages T cells endothelial cells and fibroblasts. GM-CSF interacts with its specific receptor known as CSF2 receptor to exert its effects.
Biological function summary

GM-CSF influences the immune system by enhancing the functional capacity of mature neutrophils macrophages and eosinophils. GM-CSF protein acts alone and not as part of a larger protein complex. It is important in regulating immune responses and inflammation. Due to its role in promoting the survival and activation of these immune cells GM-CSF is important for mounting an effective immune defense in response to infections and other challenges.

Pathways

GM-CSF signaling is integral to the JAK-STAT pathway. This pathway is essential for transmitting signals from surface receptors like GM-CSF receptors into the nucleus thereby inducing gene expression that leads to cell survival and proliferation. GM-CSF also intersects with the ERK1/ERK2 MAPK pathway which is involved in regulating cellular processes such as division and differentiation. The GM-CSF receptor shares similarities with other cytokine receptors involved in these pathways making it related to various cytokines through its downstream signaling effects.

GM-CSF has a well-established connection to diseases like rheumatoid arthritis and multiple sclerosis. In rheumatoid arthritis overproduction of GM-CSF is linked to chronic inflammation and joint damage. In multiple sclerosis GM-CSF might contribute to the pathological immune responses against the central nervous system. Antibodies targeting GM-CSF or its receptor represent a therapeutic strategy for these autoimmune diseases. By modulating GM-CSF activity therapeutic approaches aim to reduce inflammation and autoimmunity highlighting the protein's importance in disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
See full target information CSF2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 22:478 PubMed39375718

2024

Senescent cells promote breast cancer cells motility by secreting GM-CSF and bFGF that activate the JNK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Wang,Yan Fang,Yigong Hou,Dongmei Cheng,Emily V Dressler,Hao Wang,Juan Wang,Guanwen Wang,Yilei Li,Hong Liu,Rong Xiang,Shuang Yang,Peiqing Sun

British journal of cancer 123:438-448 PubMed32390004

2020

Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas.

Applications

Unspecified application

Species

Unspecified reactive species

Malgorzata Sielska,Piotr Przanowski,Maria Pasierbińska,Kamil Wojnicki,Katarzyna Poleszak,Bartosz Wojtas,Dominika Grzeganek,Aleksandra Ellert-Miklaszewska,Min-Chi Ku,Helmut Kettenmann,Bozena Kaminska

Cancer science 109:1949-1957 PubMed29601121

2018

PAI-1 induces Src inhibitor resistance via CCL5 in HER2-positive breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hehui Fang,Juan Jin,Doudou Huang,Fang Yang,Xiaoxiang Guan
View all publications
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