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AB106746

Anti-GM-CSF antibody [KT37]

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(1 Publication)

Rat Monoclonal GM-CSF antibody. Suitable for sELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CSF2.

View Alternative Names

GMCSF, CSF2, Granulocyte-macrophage colony-stimulating factor, GM-CSF, Colony-stimulating factor, Molgramostin, Sargramostim, CSF

1 Images
Sandwich ELISA - Anti-GM-CSF antibody [KT37] (AB106746)
  • sELISA

Unknown

Sandwich ELISA - Anti-GM-CSF antibody [KT37] (AB106746)

Sandwich ELISA using ab106746 at 5μg/ml paired with an HRP-conjugated antibody.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

KT37

Isotype

IgG2a

Carrier free

No

Reacts with

Human

Applications

sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CSF2.

P04141

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Alternative Products

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB106790

HRP Anti-GM-CSF antibody [KT35]

Sandwich ELISA - HRP Anti-GM-CSF antibody [KT35] (AB106790)

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Complementary Products

Assay Kits

AB174448

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ELISA - Human GM-CSF ELISA Kit (CSF2) (AB174448)

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Primary Antibodies

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Primary Antibodies

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Western blot - Anti-FGF21 antibody [EPR8314(2)] (AB171941)

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Primary Antibodies

AB259501

Anti-IL-17B antibody [EPR21967-267] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-IL-17B antibody [EPR21967-267] - BSA and Azide free (Capture) (AB259501)

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Primary Antibodies

AB302730

Anti-CXCL16 antibody [EPR25370-28] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-CXCL16 antibody [EPR25370-28] - BSA and Azide free (Detector) (AB302730)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "5 µg/mL", "sELISA-species-notes": "<p>Can be used as capture antibody when paired with recommended pair.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GM-CSF also known as Granulocyte-Macrophage Colony-Stimulating Factor is a glycoprotein with a mass of approximately 23 kDa. This protein plays a mechanical role in stimulating the differentiation and proliferation of hematopoietic progenitor cells into granulocytes and macrophages. Its expression occurs in various cell types including macrophages T cells endothelial cells and fibroblasts. GM-CSF interacts with its specific receptor known as CSF2 receptor to exert its effects.
Biological function summary

GM-CSF influences the immune system by enhancing the functional capacity of mature neutrophils macrophages and eosinophils. GM-CSF protein acts alone and not as part of a larger protein complex. It is important in regulating immune responses and inflammation. Due to its role in promoting the survival and activation of these immune cells GM-CSF is important for mounting an effective immune defense in response to infections and other challenges.

Pathways

GM-CSF signaling is integral to the JAK-STAT pathway. This pathway is essential for transmitting signals from surface receptors like GM-CSF receptors into the nucleus thereby inducing gene expression that leads to cell survival and proliferation. GM-CSF also intersects with the ERK1/ERK2 MAPK pathway which is involved in regulating cellular processes such as division and differentiation. The GM-CSF receptor shares similarities with other cytokine receptors involved in these pathways making it related to various cytokines through its downstream signaling effects.

GM-CSF has a well-established connection to diseases like rheumatoid arthritis and multiple sclerosis. In rheumatoid arthritis overproduction of GM-CSF is linked to chronic inflammation and joint damage. In multiple sclerosis GM-CSF might contribute to the pathological immune responses against the central nervous system. Antibodies targeting GM-CSF or its receptor represent a therapeutic strategy for these autoimmune diseases. By modulating GM-CSF activity therapeutic approaches aim to reduce inflammation and autoimmunity highlighting the protein's importance in disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
See full target information CSF2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Diseases (Basel, Switzerland) 11: PubMed37873783

2023

Systematic Evaluation of the Distribution of Immune Cells following Subcutaneous Administration of Haemophilus Influenzae Type B Vaccine to Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yao He,Yuxiu Zhao,Hongyang Liang,Xue Wang,Haoyue Lan,Dongyang Tian,Yan Li,Hui Wang
View all publications
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Product promise

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