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AB251664

Anti-GMAP-210 antibody

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(1 Publication)

Rabbit Polyclonal GMAP-210 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRIP11 aa 1-150.

View Alternative Names

CEV14, TRIP11, Thyroid receptor-interacting protein 11, TR-interacting protein 11, TRIP-11, Clonal evolution-related gene on chromosome 14 protein, Golgi-associated microtubule-binding protein 210, Trip230, GMAP-210

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-GMAP-210 antibody (AB251664)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GMAP-210 antibody (AB251664)

PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for GMAP-210 (green) using ab251664 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GMAP-210 antibody (AB251664)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GMAP-210 antibody (AB251664)

Paraffin-embedded human pancreas tissue stained for GMAP-210 using ab251664 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TRIP11 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q15643

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GMAP-210 also known as Trip11 is a large coiled-coil protein with a molecular weight of approximately 228 kDa. It primarily functions as a Golgi microtubule-associated protein playing a role in the structural integrity and organization of the Golgi apparatus. This protein is expressed in cells across various tissues highlighting its important role in maintaining proper cellular operations.
Biological function summary

GMAP-210 assists in vesicle tethering and trafficking processes ensuring the effective movement of proteins and lipids along the secretory pathway. It is not part of any large protein complex but interacts with other Golgi-associated proteins to stabilize microtubules and Golgi membranes. Its interactions are key for the correct sorting and delivery of proteins to their destinations within cells making it integral to maintaining cellular membrane dynamics.

Pathways

GMAP-210 functions significantly within the secretory pathway. It interacts with proteins essential for Golgi transport such as Golgin-84 to mediate the movement of vesicles between the Golgi stacks and other cellular compartments. Additionally GMAP-210 has roles in the regulation of the microtubule network which is vital for intracellular transport and cellular morphology maintenance.

Defects in the GMAP-210 protein are linked to achondrogenesis type 1A and can also contribute to other skeletal dysplasias. It is associated with collagen processing errors due to its role in Golgi transport which can lead to structural protein accumulation. These disorders highlight the importance of GMAP-210's interaction with proteins like collagen in maintaining normal skeletal development and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed : 25473115, PubMed : 30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed : 25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.
See full target information TRIP11
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 18:2799-2804 PubMed31452758

2019

Fibulin-2 inhibits development of gastric cancer by downregulating β-catenin.

Applications

Unspecified application

Species

Unspecified reactive species

Hongping Ma,Changhong Lian,Yingming Song
View all publications
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Product promise

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