Rabbit Polyclonal GMCL1 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GMCL1 aa 250-500.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Mouse | Predicted |
Rat | Predicted |
Cow | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/5000.00000 - 1/20000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).
BTBD13, GCL, SPATA29, GMCL1, BTBD13, SPATA29, GCL, Germ cell-less protein-like 1, Spermatogenesis-associated protein 29
Rabbit Polyclonal GMCL1 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GMCL1 aa 250-500.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
GMCL1 also known as Germ Cell-Less 1 is a protein with a molecular mass of about 55 kDa. This protein is expressed in various tissues including testis and ovary and plays a role in germ cell development. Mechanically GMCL1 is involved in nucleocytoplasmic transport and acts as a transcriptional repressor by interacting with nuclear localization sequences. It localizes mainly in the nuclear envelope and affects the translocation of other molecules through the regulation of nuclear pore complexes.
GMCL1 functions to regulate germ cell differentiation and proliferation. Through its interactions with nuclear transport factors GMCL1 helps in the modulation of gene expression. It may form a part of protein complexes although specific partners in these complexes are still under investigation. The regulation accomplished by GMCL1 is necessary for maintaining cellular structure and reproductive cell integrity.
GMCL1 plays essential roles in the germ cell development pathways and nucleocytoplasmic transport processes. It associates with proteins such as importins and exportins that mediate transport across the nuclear envelope. This protein's actions help coordinate signaling pathways that lead to proper cell cycle progression in reproductive cells supporting a functional diversity of gene expression outcomes.
GMCL1 links to infertility and certain cancers. In germ cell tumors altered GMCL1 expression patterns sometimes associate with disease states possibly due to disrupted cell cycle control. Additionally its interaction with proteins like p53 may influence cellular responses to oncogenic stress offering insights into therapeutic targets for both infertility and oncology.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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7.5% SDS PAGE
All lanes: Western blot - Anti-GMCL1 antibody (ab126041) at 1/10000 dilution
All lanes: 293T whole cell lysate at 30 µg
Predicted band size: 59 kDa
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