Skip to main content

Rabbit Polyclonal GMCL1 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GMCL1 aa 250-500.

Be the first to review this product! Submit a review

Images

Western blot - Anti-GMCL1 antibody (AB126041), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human GMCL1 aa 250-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q96IK5

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Predicted
Rat
Predicted
Cow
Predicted

Tested
Tested

Species

Human

Dilution info

1/5000.00000 - 1/20000.00000

Notes

-

Predicted
Predicted

Species

Mouse, Rat, Cow

Dilution info

-

Notes

-

Target data

Function

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal GMCL1 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GMCL1 aa 250-500.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human GMCL1 aa 250-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q96IK5
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GMCL1 also known as Germ Cell-Less 1 is a protein with a molecular mass of about 55 kDa. This protein is expressed in various tissues including testis and ovary and plays a role in germ cell development. Mechanically GMCL1 is involved in nucleocytoplasmic transport and acts as a transcriptional repressor by interacting with nuclear localization sequences. It localizes mainly in the nuclear envelope and affects the translocation of other molecules through the regulation of nuclear pore complexes.

Biological function summary

GMCL1 functions to regulate germ cell differentiation and proliferation. Through its interactions with nuclear transport factors GMCL1 helps in the modulation of gene expression. It may form a part of protein complexes although specific partners in these complexes are still under investigation. The regulation accomplished by GMCL1 is necessary for maintaining cellular structure and reproductive cell integrity.

Pathways

GMCL1 plays essential roles in the germ cell development pathways and nucleocytoplasmic transport processes. It associates with proteins such as importins and exportins that mediate transport across the nuclear envelope. This protein's actions help coordinate signaling pathways that lead to proper cell cycle progression in reproductive cells supporting a functional diversity of gene expression outcomes.

Associated diseases and disorders

GMCL1 links to infertility and certain cancers. In germ cell tumors altered GMCL1 expression patterns sometimes associate with disease states possibly due to disrupted cell cycle control. Additionally its interaction with proteins like p53 may influence cellular responses to oncogenic stress offering insights into therapeutic targets for both infertility and oncology.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Western blot - Anti-GMCL1 antibody (ab126041), expandable thumbnail

    Western blot - Anti-GMCL1 antibody (ab126041)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-GMCL1 antibody (ab126041) at 1/10000 dilution

    All lanes: 293T whole cell lysate at 30 µg

    Predicted band size: 59 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com