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AB236095

Anti-GNA14 antibody

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(1 Publication)

Rabbit Polyclonal GNA14 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GNA14 aa 1-350.

View Alternative Names

Guanine nucleotide-binding protein subunit alpha-14, G alpha-14, G-protein subunit alpha-14, GNA14

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNA14 antibody (AB236095)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNA14 antibody (AB236095)

Paraffin-embedded human prostate cancer tissue stained for GNA14 using ab236095 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-GNA14 antibody (AB236095)
  • WB

Supplier Data

Western blot - Anti-GNA14 antibody (AB236095)

All lanes:

Western blot - Anti-GNA14 antibody (ab236095) at 1/1000 dilution

All lanes:

Mouse lung tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human GNA14 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

O95837

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GNA14 also known as Guanine nucleotide-binding protein subunit alpha-14 is a component of the G protein family. This protein has a mass of approximately 41 kDa. It primarily expresses in the liver adrenal glands placenta and spleen. As a G protein it plays a role in signal transduction as part of the G alpha subunit which is an important player in relaying signals from cell surface receptors to downstream effectors within the cell.
Biological function summary

GNA14 mediates signal transduction by coupling with cell surface receptors to activate downstream signaling pathways. It functions as part of the larger heterotrimeric G protein complex interacting with G protein-coupled receptors (GPCRs). These GPCRs stimulate GNA14 which then activates intracellular signaling paths involved in various cellular responses including growth differentiation and metabolism playing an important role in maintaining cellular homeostasis.

Pathways

GNA14 participates mainly in the phospholipase C (PLC) signaling pathway where it interacts with PLC to regulate calcium ion release within the cells. This ion release affects various cellular processes such as muscle contraction and neurotransmitter release. GNA14 also shares pathway involvement with proteins like GNA13 another member of the G alpha subunit family which can have overlapping or distinct physiological roles.

GNA14 mutations have associations with conditions like uveal melanoma and Kaposiform hemangioendothelioma. In uveal melanoma GNA14 mutations affect normal signaling pathways leading to uncontrolled cell proliferation. In these diseases GNA14 does not work alone but interacts with other proteins involved in cancer pathway dysregulations such as GNAQ and BRAF implicating a complex network of molecular interactions in the pathology of such disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
See full target information GNA14
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:7248 PubMed40769964

2025

IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jan-Inge Bjune,Samantha Laber,Laurence Lawrence-Archer,Patrizia M C Nothnagel,Shuntaro Yamada,Xu Zhao,Pouda Panahandeh Strømland,Niyaz Al-Sharabi,Kamal Mustafa,Pål R Njølstad,Melina Claussnitzer,Roger D Cox,Pierre Chymkowitch,Gunnar Mellgren,Simon N Dankel
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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