Rabbit Polyclonal GNA15 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GNA15 aa 100 to C-terminus.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human GNA15 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P30679
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Alternative names
GNA16, GNA15, Guanine nucleotide-binding protein subunit alpha-15, G alpha-15, G-protein subunit alpha-15, Epididymis tissue protein Li 17E, Guanine nucleotide-binding protein subunit alpha-16, G alpha-16, G-protein subunit alpha-16
Recommended products
Rabbit Polyclonal GNA15 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GNA15 aa 100 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human GNA15 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P30679
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein GNA15 also known as G-protein subunit alpha-15 functions as part of the G protein complex which transduces signals from G protein-coupled receptors (GPCRs) to intracellular effectors. This protein weighs approximately 43 kDa. GNA15 gets expressed in various cell types with a notably higher expression in immune cells like lymphocytes and monocytes. Its role is to facilitate the transduction of external signals into a cellular response contributing to the regulation of numerous physiological processes.
- Biological function summary
GNA15 participates in signal transduction by interacting with a range of signaling molecules. This protein serves as a mediator that couples activated GPCRs to downstream effectors influencing cellular responses. GNA15 does not operate alone; it forms a part of a heterotrimeric complex composed of alpha beta and gamma subunits enabling the integration of signals that modulate cellular activities like proliferation differentiation and immune response.
- Pathways
GNA15 actively participates in intracellular signaling pathways that are critical for immune responses and cellular communication. The protein gets involved in the phospholipase C (PLC) pathway linking it with inositol trisphosphate (IP3) and diacylglycerol (DAG) production. Within this pathway it interacts with other proteins such as PLC-beta which play key roles in signal transduction. Furthermore GNA15 associates with the mitogen-activated protein kinase (MAPK) pathway impacting cell growth and survival.
- Associated diseases and disorders
GNA15 has connections to conditions involving immune function and inflammation. Aberrations in its signaling pathway have been implicated in immune disorders and inflammatory diseases such as rheumatoid arthritis. Additionally GNA15 links with other proteins like PLC-beta in the context of inflammatory signal transduction highlighting its importance in disease etiology and potential as a therapeutic target.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-GNA15 antibody (ab154157)
10% SDS PAGE
All lanes: Western blot - Anti-GNA15 antibody (ab154157) at 1/1000 dilution
All lanes: THP1 whole cell lysate at 30 µg
Predicted band size: 44 kDa
Immunocytochemistry/ Immunofluorescence - Anti-GNA15 antibody (ab154157)
Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells labeling GNA15 with ab154157 at 1/500 dilution. The image in the lower panel was co-stained with Hoechst 33342.
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