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AB154846

Anti-GNAZ antibody [EPR8654]

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(2 Publications)

Rabbit Recombinant Monoclonal GNAZ antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.

View Alternative Names

Guanine nucleotide-binding protein G(z) subunit alpha, G(x) alpha chain, Gz-alpha, GNAZ

1 Images
Western blot - Anti-GNAZ antibody [EPR8654] (AB154846)
  • WB

Unknown

Western blot - Anti-GNAZ antibody [EPR8654] (AB154846)

Dilute primary antibody in 1% BSA

All lanes:

Western blot - Anti-GNAZ antibody [EPR8654] (ab154846) at 1/1000 dilution

Lane 1:

Human fetal brain lysate at 10 µg

Lane 2:

Human cerebellum lysate at 10 µg

Lane 3:

rat brain lysate at 10 µg

Lane 4:

mouse brain lysate at 10 µg

Predicted band size: 41 kDa

false

  • Carrier free

    Anti-GNAZ antibody [EPR8654] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR8654

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p>Dilute primary antibody in 1% BSA</p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p>Dilute primary antibody in 1% BSA</p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p>Dilute primary antibody in 1% BSA</p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GNAZ also known as Guanine nucleotide-binding protein G(z) subunit alpha functions as a modulator or transducer in various transmembrane signaling systems. The protein plays an essential role in coupling cell surface receptors to intracellular signaling pathways. GNAZ weighs approximately 41.5 kDa and is widely expressed in human brain tissues and certain neuroendocrine tissues.
Biological function summary

GNAZ connects with receptor-mediated signal transduction aiding in neurotransmitter release and sensory perception. GNAZ functions as part of the heterotrimeric G-protein complex which includes G beta and G gamma subunits. This protein often regulates signal transduction cascades that influence cellular responses to external stimuli.

Pathways

GNAZ is closely linked to important signaling pathways such as the serotonergic signaling pathway and the phototransduction pathway. Within these pathways GNAZ interacts with kinases and ion channels influencing cellular responses and synaptic functions. GNAZ works alongside related proteins such as GNAI and GNAT contributing to the regulation of neurotransmitter systems.

GNAZ relates to neurological disorders and certain psychiatric conditions including schizophrenia and bipolar disorder. Changes in the activity or expression of GNAZ may impact neurotransmitter systems which are fundamental to these conditions. Through these disorders GNAZ connects with proteins like GNB and GNG pointing to its involvement in signal processing abnormalities that underlie these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
See full target information Guanine nucleotide-binding protein G(z) subunit alpha
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

eLife 11: PubMed35302493

2022

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.

Applications

Unspecified application

Species

Unspecified reactive species

Charlotte Avet,Arturo Mancini,Billy Breton,Christian Le Gouill,Alexander S Hauser,Claire Normand,Hiroyuki Kobayashi,Florence Gross,Mireille Hogue,Viktoriya Lukasheva,Stéphane St-Onge,Marilyn Carrier,Madeleine Héroux,Sandra Morissette,Eric B Fauman,Jean-Philippe Fortin,Stephan Schann,Xavier Leroy,David E Gloriam,Michel Bouvier

Frontiers in cell and developmental biology 9:724970 PubMed34527676

2021

HIV Tat-Mediated Induction of Monocyte Transmigration Across the Blood-Brain Barrier: Role of Chemokine Receptor CXCR3.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Niu,Ke Liao,Guoku Hu,Shamsudheen Moidunny,Sabita Roy,Shilpa Buch
View all publications
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Product promise

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