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AB234648

Anti-GNB1L/GY2 antibody

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(1 Publication)

Rabbit Polyclonal GNB1L/GY2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GNB1L.

View Alternative Names

GY2, KIAA1645, WDR14, FKSG1, GNB1L, Guanine nucleotide-binding protein subunit beta-like protein 1, G protein subunit beta-like protein 1, DGCRK3, WD repeat-containing protein 14, WD40 repeat-containing protein deleted in VCFS, WDVCF

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNB1L/GY2 antibody (AB234648)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNB1L/GY2 antibody (AB234648)

Paraffin-embedded human thyroid tissue stained for GNB1L/GY2 using ab234648 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNB1L/GY2 antibody (AB234648)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNB1L/GY2 antibody (AB234648)

Paraffin-embedded human kidney tissue stained for GNB1L/GY2 using ab234648 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-GNB1L/GY2 antibody (AB234648)
  • WB

Supplier Data

Western blot - Anti-GNB1L/GY2 antibody (AB234648)

All lanes:

Western blot - Anti-GNB1L/GY2 antibody (ab234648) at 1/1000 dilution

Lane 1:

Mouse brain tissue lysate

Lane 2:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human GNB1L.

Q9BYB4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The GNB1L protein also known as GY2 is a component of the beta subunit of G proteins. It has a molecular mass of approximately 37 kDa. GNB1L is found expressed in various tissues including the brain and the heart. This protein plays a significant role in signal transduction by interacting with G-protein-coupled receptors (GPCRs) and modulating their activity.
Biological function summary

The protein participates in transducing signals from receptors to effector proteins. GNB1L forms part of the larger heterotrimeric G protein complex which consists of alpha beta and gamma subunits. This complex is essential for the transmission of extracellular signals into cells facilitating various cellular responses. GNB1L contributes to the regulation of numerous physiological processes.

Pathways

With regard to pathways and its interactions GNB1L takes part in the MAPK and PI3K-Akt signaling pathways. Through these pathways the protein interacts with key proteins like Ras and Raf in the MAPK pathway or PI3K in the PI3K-Akt pathway. These interactions are important for cell cycle regulation differentiation and survival demonstrating the protein's extensive role in cellular communication networks.

The involvement of the GNB1L protein links to certain neurodevelopmental and cardiovascular disorders. Mutations or dysregulation in GNB1L can contribute to conditions like schizophrenia and congenital heart defects. In the context of these diseases the protein frequently shows associations with other proteins such as GNAS in GPCR-related pathways and KCNQ1 especially concerning cardiac function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a critical regulator of DNA damage response (DDR) signaling via specifically regulating phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.
See full target information GNB1L
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of biochemical and molecular toxicology 38:e23577 PubMed37934488

2023

Silencing of GDF11 suppresses hepatocyte apoptosis to relieve LPS/D-GalN acute liver failure.

Applications

Unspecified application

Species

Unspecified reactive species

Rongsheng Zhou,Shuang Li,Qun Wang,Yang Bi,Xiaogang Li,Qiang Wang
View all publications
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Product promise

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