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AB317373

Anti-GNB2 antibody [S04-1A2]

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Rabbit Recombinant Monoclonal GNB2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Synthetic Peptide within Human Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2.

View Alternative Names

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2, G protein subunit beta-2, Transducin beta chain 2, GNB2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNB2 Antibody [S04-1A2] (AB317373)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNB2 Antibody [S04-1A2] (AB317373)

Immunohistochemistry of GNB2 in paraffin-embedded human cholangiocarcinoma using ab317373 at dilution 1/20.

Western blot - Anti-GNB2 Antibody [S04-1A2] (AB317373)
  • WB

Supplier Data

Western blot - Anti-GNB2 Antibody [S04-1A2] (AB317373)

All lanes:

Western blot - Anti-GNB2 Antibody [S04-1A2] (ab317373) at 1/1000 dilution

Lane 1:

Rat brain lysate

Lane 2:

C6 cell lysate

Lane 3:

NIH3T3 cell lysate

Lane 4:

HeLa cell lysate

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

S04-1A2

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse, Rat

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2.

P62879

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GNB2 also known as Guanine Nucleotide Binding Protein Subunit Beta 2 is part of the G protein family. It has a molecular mass of approximately 38 kDa. GNB2 functions mechanically by acting as a modulator or transducer in various signaling pathways. This protein is expressed in a wide range of tissues including the brain heart and muscles. Its role involves interacting with alpha and gamma subunits to form a heterotrimeric G protein complex that is important for signal transduction.
Biological function summary

In the context of cellular processes GNB2 is involved in transmitting signals from activated G protein-coupled receptors to different intracellular effectors. It forms an essential part of the G protein complex which plays a role in facilitating the exchange of GDP for GTP on the alpha subunit. The activation of the G protein complex enables downstream signaling that governs multiple physiological responses such as sensory perception and cellular communication.

Pathways

GNB2 is heavily involved in pathways related to signal transduction and sensory perception. It plays a significant role within the GPCR (G protein-coupled receptor) signaling pathway an important pathway involved in transmitting signals from diverse stimuli outside a cell to its interior. In this context GNB2 interacts with related proteins such as GNAI2 contributing to the regulation of ion channels adenylyl cyclases and other effectors. This connectivity enables precise cellular responses to external signals.

Research indicates that GNB2 is associated with cardiac arrhythmias and neuropsychiatric disorders. It has connections to other proteins like GNAO1 in the context of these conditions. Mutations or dysregulation of GNB2 can disrupt normal signaling processes leading to these diseases. Understanding the role of GNB2 in these disorders highlights potential therapeutic targets for developing new interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
See full target information Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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