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AB126562

Anti-GNG13 antibody

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(2 Publications)

Rabbit Polyclonal GNG13 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 aa 1 to C-terminus.

View Alternative Names

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13, GNG13

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG13 antibody (AB126562)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG13 antibody (AB126562)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling GNG13 with ab126562 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG13 antibody (AB126562)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG13 antibody (AB126562)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human eye retina tissue labelling GNG13 with ab126562 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG13 antibody (AB126562)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG13 antibody (AB126562)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebellum tissue labelling GNG13 with ab126562 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG13 antibody (AB126562)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG13 antibody (AB126562)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human duodenum tissue labelling GNG13 with ab126562 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9P2W3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GNG13 also known as Guanine Nucleotide-Binding Protein Subunit Gamma-13 is a part of the larger family of G protein gamma subunits. It participates in signal transduction by coupling cell surface receptors with internal signaling pathways. GNG13 has a molecular mass of approximately 8.7 kDa. Researchers have found it expressed in tissues such as the retina and olfactory epithelium where it plays a role in sensory perception and signal transmission.
Biological function summary

GNG13 functions as a component of the heterotrimeric G protein complex which includes alpha and beta subunits. Within these complexes GNG13 works to regulate the response of cells to various external signals. Its presence in the retina suggests a function in visual signal processing. Additionally in the olfactory system GNG13 contributes to the detection of odor molecules helping organisms respond to environmental cues.

Pathways

Information about GNG13 indicates significant involvement in the visual transduction and olfactory signaling pathways. Within the visual pathway GNG13 interacts with proteins like GNRH1 which is critical for transmitting light signals to the brain. In the olfactory pathway GNG13 works alongside other signaling proteins to convey information about smells to the central nervous system facilitating adaptive and survival-oriented behavioral responses.

Evidence links GNG13 dysfunction to usher syndrome and retinitis pigmentosa. Usher syndrome known for causing a combination of hearing loss and visual impairment suggests possible interactions with proteins such as USH2A which have roles in sensory processing. Retinitis pigmentosa a progressive retinal disorder ties GNG13 to retinal cell degeneration underlining its importance in retinal health and function. Further study into GNG13 and its interacting proteins may reveal new therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
See full target information Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Pathology, research and practice 216:153143 PubMed32853961

2020

High expression of G protein subunit gamma 13 is associated with poor prognosis of gastrointestinal stromal tumor.

Applications

Unspecified application

Species

Unspecified reactive species

Ke-Cheng Ju,Bin Zhang,Yi-Lin Hu,Ying Feng,Xiao-Hong Li,Yi-Fei Liu,Peng Li,Qin-Sheng Mao,Wan-Jiang Xue

Nature 560:319-324 PubMed30069044

2018

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel T Montoro,Adam L Haber,Moshe Biton,Vladimir Vinarsky,Brian Lin,Susan E Birket,Feng Yuan,Sijia Chen,Hui Min Leung,Jorge Villoria,Noga Rogel,Grace Burgin,Alexander M Tsankov,Avinash Waghray,Michal Slyper,Julia Waldman,Lan Nguyen,Danielle Dionne,Orit Rozenblatt-Rosen,Purushothama Rao Tata,Hongmei Mou,Manjunatha Shivaraju,Hermann Bihler,Martin Mense,Guillermo J Tearney,Steven M Rowe,John F Engelhardt,Aviv Regev,Jayaraj Rajagopal
View all publications
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Product promise

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