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AB238868

Anti-GNG4 antibody

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(3 Publications)

Rabbit Polyclonal GNG4 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GNG4.

View Alternative Names

GNGT4, GNG4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG4 antibody (AB238868)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG4 antibody (AB238868)

Paraffin-embedded human pancreas tissue stained for GNG4 using ab238868 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG4 antibody (AB238868)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNG4 antibody (AB238868)

Paraffin-embedded human kidney tissue stained for GNG4 using ab238868 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-GNG4 antibody (AB238868)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GNG4 antibody (AB238868)

HepG2 (Human liver hepatocellular carcinoma cell line) cells stained for GNG4 (green) using ab238868 at 1/100 dilution in ICC/IF. Secondary antibody is an Alexa-Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human GNG4.

P50150

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The G-protein gamma subunit 4 also known as GNG4 is a component of the heterotrimeric G-protein complex. It has a molecular mass of approximately 7.9 kDa. This protein is typically expressed in various tissues including the brain and spinal cord. Functionally GNG4 is involved in signal transduction processes by forming a complex with the G-protein beta subunit playing a critical role in transmitting signals from G-protein-coupled receptors (GPCRs) to downstream effectors.
Biological function summary

GNG4 participates in the modulation of intracellular signal pathways. It forms an integral part of the G-protein complex which includes another subunit known as GNB1. This complex is necessary for proper functioning of GPCR-mediated signaling. The G-protein complex influences various cellular responses by affecting ion channels enzymes and other intracellular pathways. The presence of GNG4 in neuronal tissues suggests its role in neurotransmission and the potential influence on neurologic function.

Pathways

GNG4 plays a role in the adenylyl cyclase signaling pathway and the phospholipase C pathway. In both pathways GNG4 together with GNB1 regulates the conversion of extracellular signals into intracellular actions. These actions include cyclic AMP production or calcium ion release which subsequently affect cellular activities. This involvement links GNG4 to various cellular processes by mediating inputs from diverse signals through its interaction with GPCR-related pathways.

GNG4 is associated with conditions such as neuropsychiatric disorders and cancer. The aberrant expression or mutation of GNG4 can disrupt normal signaling pathways contributing to disease pathology. In neuropsychiatric disorders GNG4 interacts with dopamine receptor pathways affecting dopaminergic signaling; this connection suggests a possible link to conditions like schizophrenia. In cancer altered GNG4 expression has been observed in some tumor types indicating its potential involvement in tumorigenesis through signaling pathways linked to other proteins such as Ras.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
See full target information GNG4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Bioengineered 12:7849-7858 PubMed34635014

2021

MicroRNA miR-19b-3p mediated G protein γ subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xia Zhao,Xiang-Cheng Zhang,Kui Zang,Zhi-Hao Yu

Molecular medicine reports 24: PubMed34080026

2021

HIGD‑1B inhibits hypoxia‑induced mitochondrial fragmentation by regulating OPA1 cleavage in cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Pang,Zhide Zhu,Zhihao Wen,Junshen Lu,Hao Lin,Meiling Tang,Zhiliang Xu,Jianqi Lu

Oncology letters 20:334 PubMed33123245

2020

Molecular heterogeneity of guanine nucleotide binding-protein γ subunit 4 in left- and right-sided colon cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jintian Song,Jianwei Yang,Rongbo Lin,Xiongchao Cai,Liang Zheng,Yigui Chen
View all publications
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Product promise

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