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AB243448

Anti-GNGT1 antibody

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(1 Publication)

Rabbit Polyclonal GNGT1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Guanine nucleotide-binding protein G(T) subunit gamma-T1 aa 1-50.

View Alternative Names

Guanine nucleotide-binding protein G(T) subunit gamma-T1, Transducin gamma chain, GNGT1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNGT1 antibody (AB243448)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNGT1 antibody (AB243448)

Formalin-fixed, paraffin-embedded human retina tissue stained for GNGT1 with ab243448 at a 1/1000 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Guanine nucleotide-binding protein G(T) subunit gamma-T1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P63211

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GNGT1 also known as guanine nucleotide-binding protein G(t) subunit gamma-1 is a critical component of the heterotrimeric G-protein complex. With a molecular mass of approximately 8 kDa GNGT1 is highly expressed in the retina and pineal gland. It plays an essential role in signal transduction processes by participating in the interaction with the alpha and beta subunits of the G-protein heterotrimer which is important for transmitting signals from activated receptors to intracellular effectors.
Biological function summary

The gamma subunit's interaction with the beta subunit forms a stable dimer which is vital for the proper functioning of G-proteins. GNGT1 as part of this beta-gamma complex modulates the activity of specific receptors linked to neurotransmission and sensory reception. This complex's significance is realized in phototransduction within the retinal cells where it supports the transmission of visual signals by regulating cGMP levels and phosphodiesterase activity.

Pathways

This protein plays a pivotal role in the phototransduction and Ras signaling pathways. In phototransduction GNGT1 contributes to the regulation of visual pigment signaling by interacting with transducin a protein related to the G(alpha) subunit of the pathway. It influences the biochemical cascade that enables the conversion of visual signals into nerve impulses. Moreover through Ras signaling GNGT1 influences pathways involved in cell growth extending its functional implications beyond sensory perception.

Mutations or dysregulation of GNGT1 have been implicated in retinitis pigmentosa and congenital stationary night blindness. These conditions reflect the protein's important role in retinal function and the visual cycle. Additionally the association between GNGT1 and transducin signals a pathway distortion in these diseases where improper signaling can lead to progressive retinal degeneration or impaired vision function. Understanding GNGT1 in these contexts is key for potential therapeutic targeting and intervention in retinal disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
See full target information Guanine nucleotide-binding protein G(T) subunit gamma-T1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology 37:1007-1017 PubMed35548923

2022

Significance of Anoctamin 6 in progression and prognostic prediction of gastric adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Li,Qiong Fan,Li Zheng,Peng Liu,Nian Fang
View all publications
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