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AB106363

Anti-GNPDA2 antibody

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(4 Publications)

Rabbit Polyclonal GNPDA2 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human GNPDA2.

View Alternative Names

GNP2, GNPDA2, Glucosamine-6-phosphate isomerase 2, Glucosamine-6-phosphate deaminase 2, Glucosamine-6-phosphate isomerase SB52, GNPDA 2, GlcN6P deaminase 2

2 Images
Immunocytochemistry - Anti-GNPDA2 antibody (AB106363)
  • ICC

Unknown

Immunocytochemistry - Anti-GNPDA2 antibody (AB106363)

Immunocytochemical analysis of Human GNPDA2 in 293 cells stained with ab106363 at 4 μg/mL.

Western blot - Anti-GNPDA2 antibody (AB106363)
  • WB

Unknown

Western blot - Anti-GNPDA2 antibody (AB106363)

All lanes:

Western blot - Anti-GNPDA2 antibody (ab106363) at 1 µg/mL

All lanes:

Human kidney lysate at 15 µg

Predicted band size: 31 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC

applications

Immunogen

Synthetic Peptide within Human GNPDA2. The exact immunogen used to generate this antibody is proprietary information.

Q8TDQ7

Specificity

ab106363 is predicted not to cross-react with GNPDA1.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "4 µg/mL", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The GNPDA2 protein also known as glucosamine-6-phosphate deaminase 2 has a molecular mass of approximately 33 kDa. It functions mechanically by catalyzing the conversion of glucosamine-6-phosphate to fructose-6-phosphate and ammonia. Its expression occurs in various tissues including the brain liver and adipose tissue. GNPDA2’s enzymatic activity is significant for the regulation of amino sugar and nucleotide sugar metabolism.
Biological function summary

GNPDA2 plays a role in metabolic processes affecting cellular growth and energy production. Although GNPDA2 does not typically form complexes it serves as a single-function enzyme critical to metabolic signaling within cells. Its enzymatic function supports broader cellular activities by mediating sugar metabolism therefore impacting cellular pathways related to metabolism.

Pathways

GNPDA2 contributes to the hexosamine biosynthetic pathway an important route in carbohydrate metabolism. This pathway intersects with the glycolysis pathway and involves enzymes like phosphoglucosamine mutase and hexokinase. GNPDA2’s action in these pathways is important for cellular energy regulation and synthesis of amino sugars necessary for glycosylation processes.

Research links GNPDA2 to obesity and type 2 diabetes. Genetic variants of GNPDA2 have associations with alterations in body mass index impacting metabolic regulation in these conditions. GNPDA2 interacts with proteins such as leptin and insulin which are critical in these disorders affecting metabolic signaling and insulin sensitivity. The protein's role emphasizes its importance in complex metabolic conditions affecting human health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling.
See full target information GNPDA2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 14: PubMed38672412

2024

Involvement of Glucosamine 6 Phosphate Isomerase 2 (GNPDA2) Overproduction in β-Amyloid- and Tau P301L-Driven Pathomechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Mercedes Lachén-Montes,Paz Cartas-Cejudo,Adriana Cortés,Elena Anaya-Cubero,Erika Peral,Karina Ausín,Ramón Díaz-Peña,Joaquín Fernández-Irigoyen,Enrique Santamaría

Biomedicines 10: PubMed36289871

2022

Obesity-Related Genes Expression in Testes and Sperm Parameters Respond to GLP-1 and Caloric Restriction.

Applications

Unspecified application

Species

Unspecified reactive species

Ana S Correia,Sara C Pereira,Tiago Morais,Ana D Martins,Mariana P Monteiro,Marco G Alves,Pedro F Oliveira

Cancers 13: PubMed33435319

2021

Comprehensive Assessment of Copy Number Alterations Uncovers Recurrent and Copy Gain in Medullary Thyroid Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Aline Neves Araujo,Cléber Pinto Camacho,Thais Biude Mendes,Susan Chow Lindsey,Lais Moraes,Marta Miyazawa,Rosana Delcelo,Renata Pellegrino,Diego Robles Mazzotti,Rui Monteiro de Barros Maciel,Janete Maria Cerutti

Journal of cellular physiology 236:5265-5277 PubMed33368221

2020

Obesity-related genes are expressed in human Sertoli cells and modulated by energy homeostasis regulating hormones.

Applications

Unspecified application

Species

Unspecified reactive species

Sara C Pereira,Ana C Martins,Bruno P Moreira,Raquel L Bernardino,Alberto Barros,Mariana P Monteiro,Pedro F Oliveira,Marco G Alves
View all publications
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