AB202848

Anti-GnRHR antibody

Name: Anti-GnRHR antibody (ab202848) | Abcam
Brand: Abcam Limited
SKU: AB202848
Rating: 4 (1 reviews)

(1 Review)

(8 Publications)

Rabbit Polyclonal GNRHR antibody. Suitable for IHC-P and reacts with Rat, Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human GNRHR aa 200-300 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

GRHR, GNRHR, Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GnRHR antibody (AB202848)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GnRHR antibody (AB202848)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human breast cancer tissue labeling GnRHR with ab202848 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GnRHR antibody (AB202848)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Rat brain tissue labeling GnRHR with ab202848 at 1/200 dilution, followed by Goat Anti-Rabbit IgG, Cy3 conjugated secondary antibody at 1/200 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GnRHR antibody (AB202848)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Rat brain tissue labeling GnRHR with ab202848 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GNRHR aa 200-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P30968

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GnRHR also known as the Gonadotropin-releasing hormone receptor is a G-protein coupled receptor that plays an important role in the reproductive system. This receptor has a molecular mass of approximately 37 kDa. GnRHR is mainly expressed in the pituitary gland but it is also found in other tissues like the ovary and prostate. Its primary function is to bind to the GnRH ligand which triggers the release of hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Biological function summary

The GnRHR is involved in regulating reproductive functions by mediating the action of GnRH at the pituitary level. It does not form part of larger complex structures like some other receptors might. This interaction leads to a second messenger cascade mainly involving phospholipase C which increases intracellular calcium levels. In turn hormone secretion is stimulated leading to gametogenesis and steroidogenesis.

Pathways

The GnRHR is integral to the hypothalamic-pituitary-gonadal (HPG) axis an important regulatory pathway in reproductive endocrinology. It works closely with proteins like FSH and LH which are essential for proper sexual development and reproductive health. The receptor activation initiates signaling pathways leading to the transcription of genes responsible for reproductive maturation and function.

GnRHR is notably associated with conditions like hypogonadotropic hypogonadism and polycystic ovary syndrome (PCOS). Mutations or malfunctions in this receptor or GnRH can lead to insufficient gonadotropin release. This malfunction disrupts the regular hormonal feedback loop necessary for reproduction. Furthermore altered signaling through GnRHR has connections to neoplastic disorders in tissues where it is expressed linking it to cancer pathways where proteins such as kisspeptin can also play a role.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.

See full target information GNRHR

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:29037 PubMed40781494

2025

Reproductive toxicity in male rats induced by chronic arsenic exposure involves hormonal and structural changes.

Applications

Unspecified application

Species

Unspecified reactive species

Syed Zahid Mahboob,Sarwat Jahan,Hussain Badshah,Razia Virk,Mehwish David,Riffat Bano,Jawaher Alzahrani,Muhammad Ayub,Azizullah Azizullah,Moona Nazish,Asif Kamal,Kamran Ullah,Muhammad Tahir Naseem

Frontiers in endocrinology 16:1579031 PubMed40405980

2025

Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yaoyao Zhu,Ge Lu,Weixin Li,Chenchen Su,Pengfei Du,Shuyou Wang,Li Yang,Huanfang Xu,Yigong Fang,Xiaojing Song

Toxics 11: PubMed37755799

2023

Impact of Perinatal Coexposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs.

Applications

Unspecified application

Species

Unspecified reactive species

Marwa Lahimer,Narimane Djekkoun,Sophian Tricotteaux-Zarqaoui,Aurélie Corona,Isabelle Lafosse,Habib Ben Ali,Mounir Ajina,Véronique Bach,Moncef Benkhalifa,Hafida Khorsi-Cauet

International journal of medical sciences 19:1442-1450 PubMed36035370

2022

GnRH receptor mediates lipid storage in female adipocytes via AMPK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyong Li,Xueyan Zhang,Zhaojun Shen,Zhengyun Chen,Hanzhi Wang,Xinmei Zhang

Evidence-based complementary and alternative medic 2020:8895809 PubMed33204296

2020

Ziyin Bushen Decoction Alleviates Perimenopausal Syndrome in Rats by Enhancing Estradiol Production.

Applications

Unspecified application

Species

Unspecified reactive species

Bi-Xin Tang,Qing-Yi Meng,Chan Xie,Shen-Shen Zhao,Kun-Lun Wu,Fang Wang,Le-Yi Du

Biochemical and biophysical research communication 529:104-111 PubMed32560810

2020

Effects of leptin on HPG axis and reproductive function in male rat in simulated altitude of 5500 m hypoxia environment.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyuan Liu,Shiying Liu,Chengli Xu

Neurourology and urodynamics 37:1574-1582 PubMed30133853

2018

Administration of leuprolide acetate, a GnRH agonist, improves urodynamic parameters in ovariectomized rats.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Medina-Aguiñaga,Alvaro Munoz,Maricela Luna,Carlos G Martinez-Moreno,Andrés Quintanar-Stephano,J Luis Quintanar

Food and chemical toxicology : an international jo 116:11-19 PubMed29627501

2018

Prenatal exposure to zearalenone disrupts reproductive potential and development via hormone-related genes in male rats.

Applications

Species

Unspecified reactive species

Xin Gao,Zhuohui Xiao,Chong Li,Jiacai Zhang,Luoyi Zhu,Lvhui Sun,Niya Zhang,Mahmoud Mohamed Khalil,Shahid Ali Rajput,Desheng Qi

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GnRHR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GnRHR antibody (AB202848)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GnRHR antibody (AB202848)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GnRHR antibody (AB202848)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (8)

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