Mouse Monoclonal GNRHR antibody. Suitable for ICC, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GNRHR.
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA
ICC | IHC-P | |
---|---|---|
Human | Tested | Tested |
Cow | Predicted | Predicted |
Dog | Predicted | Predicted |
Horse | Predicted | Predicted |
Pig | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1-2 µg/mL | Notes Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Horse, Cow, Dog, Pig | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1-2 µg/mL | Notes Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Horse, Cow, Dog, Pig | Dilution info - | Notes - |
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Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
GRHR, GNRHR, Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R
Mouse Monoclonal GNRHR antibody. Suitable for ICC, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GNRHR.
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA
GnRHR also known as the Gonadotropin-releasing hormone receptor is a G-protein coupled receptor that plays an important role in the reproductive system. This receptor has a molecular mass of approximately 37 kDa. GnRHR is mainly expressed in the pituitary gland but it is also found in other tissues like the ovary and prostate. Its primary function is to bind to the GnRH ligand which triggers the release of hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
The GnRHR is involved in regulating reproductive functions by mediating the action of GnRH at the pituitary level. It does not form part of larger complex structures like some other receptors might. This interaction leads to a second messenger cascade mainly involving phospholipase C which increases intracellular calcium levels. In turn hormone secretion is stimulated leading to gametogenesis and steroidogenesis.
The GnRHR is integral to the hypothalamic-pituitary-gonadal (HPG) axis an important regulatory pathway in reproductive endocrinology. It works closely with proteins like FSH and LH which are essential for proper sexual development and reproductive health. The receptor activation initiates signaling pathways leading to the transcription of genes responsible for reproductive maturation and function.
GnRHR is notably associated with conditions like hypogonadotropic hypogonadism and polycystic ovary syndrome (PCOS). Mutations or malfunctions in this receptor or GnRH can lead to insufficient gonadotropin release. This malfunction disrupts the regular hormonal feedback loop necessary for reproduction. Furthermore altered signaling through GnRHR has connections to neoplastic disorders in tissues where it is expressed linking it to cancer pathways where proteins such as kisspeptin can also play a role.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human ovarian carcinoma tissue labeling GnRHR with ab220196 at 2 μg/ml dilution.
Immunocytochemistry analysis of MeOH-fixed MCF-7 cells labeling GnRHR with ab220196 at 2ug/mL followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).
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