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AB223043

Anti-GOLGA3 antibody

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(1 Publication)

Rabbit Polyclonal GOLGA3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Golgin subfamily A member 3 aa 200-450.

View Alternative Names

Golgin subfamily A member 3, Golgi complex-associated protein of 170 kDa, Golgin-160, GCP170, GOLGA3

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-GOLGA3 antibody (AB223043)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GOLGA3 antibody (AB223043)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for GOLGA3 (green) using ab223043 at 1/100 dilution in ICC/IF. Secondary : Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLGA3 antibody (AB223043)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLGA3 antibody (AB223043)

Paraffin-embedded human brain tissue stained for GOLGA3 using ab223043 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLGA3 antibody (AB223043)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLGA3 antibody (AB223043)

Paraffin-embedded human adrenal gland tissue stained for GOLGA3 using ab223043 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Golgin subfamily A member 3 aa 200-450. The exact immunogen used to generate this antibody is proprietary information.

Q08378

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The GOLGA3 protein also known as Golgin subfamily A member 3 is a structural protein located in the Golgi apparatus. GOLGA3 has a mass of about 170 kDa. Researchers found its expression in various cell types but it has enhanced expression in testes. GOLGA3 participates in maintaining the structural integrity of the Golgi apparatus where it helps tether and organize the Golgi membrane stacks ensuring proper protein and lipid trafficking within the cell.
Biological function summary

GOLGA3 contributes to the assembly and function of the Golgi structure and is part of a complex network of Golgi-associated proteins. This network is involved in intracellular vesicle movement and membrane trafficking. GOLGA3 interacts with other golgin members to facilitate transport processes critical for maintaining cellular homeostasis affecting the secretory pathway and protein sorting within the cell.

Pathways

GOLGA3 plays roles in the Golgi transport and vesicle-mediated transport pathways. It is associated with proteins such as RABs which are small GTPases regulating vesicle movement and COPI which assists in retrograde Golgi-to-ER transport. Through these interactions GOLGA3 influences the functionality of these pathways particularly those engaged in the dynamic processes of cargo sorting and ER-to-Golgi transport.

Researchers link GOLGA3 to certain reproductive and neurological conditions. In testicular tissue dysregulation of GOLGA3 could contribute to conditions like infertility due to its role in spermatogenesis. It also connects to Alzheimer's disease where its interaction with the amyloid precursor protein (APP) may influence APP trafficking and processing. Understanding the link between GOLGA3 and these diseases may uncover new therapeutic possibilities.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Golgi auto-antigen; probably involved in maintaining Golgi structure.
See full target information Golgin subfamily A member 3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell science 136: PubMed37039765

2023

Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Danya Abazari,Angela R Wild,Tian Qiu,Bryan C Dickinson,Shernaz X Bamji
View all publications
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Product promise

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