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AB92612

Anti-GOLPH2 antibody

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(3 Publications)

Rabbit Polyclonal GOLPH2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GOLM1.

View Alternative Names

C9orf155, GOLPH2, PSEC0242, UNQ686/PRO1326, GOLM1, Golgi membrane protein 1, Golgi membrane protein GP73, Golgi phosphoprotein 2

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-GOLPH2 antibody (AB92612)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GOLPH2 antibody (AB92612)

Immunofluorescence of GOLPH2 in rat brain tissue with ab92612 at 20 ug/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH2 antibody (AB92612)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH2 antibody (AB92612)

Immunohistochemistry of rat brain tissue with ab92612 at 2.5 μg/mL.

Western blot - Anti-GOLPH2 antibody (AB92612)
  • WB

Unknown

Western blot - Anti-GOLPH2 antibody (AB92612)

Lane 1:

Western blot - Anti-GOLPH2 antibody (ab92612) at 0.25 µg/mL

Lane 2:

Western blot - Anti-GOLPH2 antibody (ab92612) at 0.5 µg/mL

All lanes:

Rat brain tissue lysate at 15 µg

Predicted band size: 45 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human GOLM1. The exact immunogen used to generate this antibody is proprietary information.

Q8NBJ4

Specificity

ab92612 will not recognize GOLPH1 or GOLPH3.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.25-0.5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GOLPH2 also known as GOLM1 or Golgi membrane protein 1 has a significant mechanical role in the cell. It is a 73-kilodalton protein found mainly in the Golgi apparatus. This protein gets expressed in various tissues with notable levels in the liver and other organs involved in secretion. It acts as a transmembrane protein in the Golgi where it helps in processing and sorting secretory proteins influencing how proteins move through secretory pathways.
Biological function summary

GOLPH2 plays an essential role in maintaining Golgi function and efficient protein trafficking. It does not belong to a large protein complex but its proper functioning is critical for handling secretory pathways. The protein keeps secretory flow organized which affects cellular responses and interactions with the environment. The GOLPH2 protein also has connections to immunity responding to stimuli like infections or inflammation.

Pathways

GOLPH2 actively participates in secretory pathways and protein transport systems. Its role includes coordination with other Golgi proteins to facilitate protein modification and sorting. GOLPH2 interacts with other proteins like GOLM1 and GOLPH3 impacting the Golgi's structural organization and influencing pathways like vesicular transport. These interactions are important for adapting the intracellular environment to external demands.

GOLPH2 levels change in diseases such as liver cancer and hepatitis. These changes can serve as biomarkers for diagnosis and disease progression monitoring. GOLPH2 also connects with proteins involved in these diseases including AFP a known tumor marker. Understanding GOLPH2's role in such conditions aids research in developing diagnostic tools and therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Unknown. Cellular response protein to viral infection.
See full target information GOLM1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Oncology reports 47: PubMed35211762

2022

Cepharanthine hydrochloride inhibits the Wnt/β‑catenin/Hedgehog signaling axis in liver cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Gui-Feng Su,Ze-Xiu Huang,Deng-Liang Huang,Peng-Xiao Chen,Yao Wang,Yi-Fei Wang

Nature communications 12:7004 PubMed34853313

2021

GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Yumeng Peng,Qiang Zeng,Luming Wan,Enhao Ma,Huilong Li,Xiaopan Yang,Yanhong Zhang,Linfei Huang,Haotian Lin,Jiangyue Feng,Yixin Xu,Jingfei Li,Muyi Liu,Jing Liu,Changqin Lin,Zhiwei Sun,Gong Cheng,Xuemiao Zhang,Jialong Liu,Dongrui Li,Meng Wei,Yunhai Mo,Xuetao Mu,Xiaowei Deng,Dandan Zhang,Siqing Dong,Hanqing Huang,Yi Fang,Qi Gao,Xiaoli Yang,Feixiang Wu,Hui Zhong,Congwen Wei

American journal of cancer research 10:3705-3720 PubMed33294262

2020

GOLM1 upregulates expression of PD-L1 through EGFR/STAT3 pathway in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jiuliang Yan,Binghai Zhou,Lei Guo,Zheng Chen,Bo Zhang,Shuang Liu,Wentao Zhang,Mincheng Yu,Yongfeng Xu,Yongsheng Xiao,Jian Zhou,Jia Fan,Hui Li,Qinghai Ye
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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