JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB238876

Anti-GOLPH3L antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal GOLPH3L antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GOLPH3L aa 1 to C-terminus.

View Alternative Names

GPP34R, GOLPH3L, Golgi phosphoprotein 3-like, GPP34-related protein

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH3L antibody (AB238876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH3L antibody (AB238876)

Paraffin-embedded human colon cancer tissue stained for GOLPH3L with ab238876 at a 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH3L antibody (AB238876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GOLPH3L antibody (AB238876)

Paraffin-embedded human melanoma tissue stained for GOLPH3L with ab238876 at a 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human GOLPH3L aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9H4A5

style
left-column

Complementary Products

Primary Antibodies

AB98023

Anti-GOLPH3/MIDAS antibody

Immunocytochemistry/ Immunofluorescence - Anti-GOLPH3/MIDAS antibody (AB98023)

  • 5
  • 2
Primary Antibodies

AB238875

Anti-LY6H antibody

Immunocytochemistry/ Immunofluorescence - Anti-LY6H antibody (AB238875)

  • 0
  • 0
Primary Antibodies

AB176689

Anti-ZNF384 antibody

Immunoprecipitation - Anti-ZNF384 antibody (AB176689)

  • 5
  • 1
Primary Antibodies

AB237050

Anti-CBWD2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CBWD2 antibody (AB237050)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GOLPH3L also known as Golgi phosphoprotein 3-like is a protein with a molecular mass of approximately 34 kDa. This protein is located in the Golgi apparatus within cells where it plays a significant role in maintaining the Golgi's structure and function. It is expressed across various human tissues though its concentration varies suggesting its differential involvement based on cellular context and function.
Biological function summary

Proteins like GOLPH3L are engaged in the regulation of secretory pathways. While GOLPH3L does not form a complex on its own it shares functional similarities with GOLPH3 which is part of larger protein interactions within the Golgi apparatus. These proteins are believed to modulate the vesicular transport that is important for cellular trafficking and protein sorting.

Pathways

Scientists have identified GOLPH3L as a component of the PI3K/AKT/mTOR signaling pathway impacting cellular growth and metabolism. This pathway is vital for cell survival and proliferation with GOLPH3L interacting with components such as GOLPH3 to influence these processes. Furthermore this protein can impact the secretory pathway by altering Golgi-mediated transport linking it to broader physiological mechanisms.

GOLPH3L's function connects to certain cancers and neurological conditions. Variations in its expression and activity may contribute to the progression of conditions like glioblastoma where PI3K/AKT/mTOR pathway dysregulation is common. Researchers have shown that interaction with GOLPH3 can exacerbate these effects highlighting its potential role in disease progression and as a target for therapeutic interventions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.
See full target information GOLPH3L
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 25:105358 PubMed36339256

2022

Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non-small-cell lung carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hyoung-Oh Jeong,Hayoon Lee,Hyemin Kim,Jinho Jang,Seunghoon Kim,Taejoo Hwang,David Whee-Young Choi,Hong Sook Kim,Naeun Lee,Yoo Mi Lee,Sehhoon Park,Hyun Ae Jung,Jong-Mu Sun,Jin Seok Ahn,Myung-Ju Ahn,Keunchil Park,Semin Lee,Se-Hoon Lee
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com