Rabbit Polyclonal GP2 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Pancreatic secretory granule membrane major glycoprotein GP2 aa 1-200.
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Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human Pancreatic secretory granule membrane major glycoprotein GP2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link P55259
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
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Target data
Function
Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.
Alternative names
Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75, GP2
Recommended products
Rabbit Polyclonal GP2 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Pancreatic secretory granule membrane major glycoprotein GP2 aa 1-200.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human Pancreatic secretory granule membrane major glycoprotein GP2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link P55259
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GP2 also known as Glycoprotein 2 is an important protein with a molecular mass of about 78 kDa. It mainly expresses in pancreatic acinar cells and the epithelial cells of the gastrointestinal tract. GP2 is anchored to the zymogen granule membrane through a glycosylphosphatidylinositol (GPI) anchor which facilitates its release into the lumen. It plays a mechanical role in the stabilization and release of digestive enzymes contributing to proper digestive processes.
- Biological function summary
GP2 interacts with the innate immune system by binding to pathogens such as bacteria. It forms part of the mucosal defense system within the gastrointestinal tract. GP2 acts by trapping pathogens marking them for further immune processing. It also associates with membrane proteins like lactoferrin that help modulate immune response. Through its involvement in pathogen recognition and response GP2 supports a healthy gut environment and prevents infections.
- Pathways
GP2 participates in immune-related processes and pathways. One significant pathway includes the mannose-binding lectin (MBL) pathway where GP2 works together with lectins and complement proteins to mediate the identification and clearance of pathogens. GP2's interactions with the complement system overlap with proteins like C3 linking it to a broader immune surveillance network. These interactions position GP2 as a pivotal component in maintaining gut mucosal immunity.
- Associated diseases and disorders
Impaired GP2 function associates with inflammatory bowel disease (IBD) and pancreatitis. Altered expression or mutation of GP2 may compromise defensive capabilities in the gut leading to chronic inflammation as seen in Crohn's disease or ulcerative colitis. Additionally improper GP2 function can result in pancreatitis a condition where enzymes prematurely activate and damage the pancreas. In both disorders GP2’s connection to proteins involved in immune pathways such as lactoferrin and C3 highlights its importance in protecting against excessive inflammation.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GP2 antibody (ab224383)
Paraffin-embedded human pancreas tissue stained for GP2 using ab224383 at 1/1000 dilution in immunohistochemical analysis.
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