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AB231592

Anti-GPA33 antibody

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(1 Publication)

Rabbit Polyclonal Glycoprotein A33 antibody. Suitable for WB and reacts with Rat, Recombinant full length protein - Rat, Mouse samples. Cited in 1 publication.
2 Images
Western blot - Anti-GPA33 antibody (AB231592)
  • WB

Supplier Data

Western blot - Anti-GPA33 antibody (AB231592)

All lanes:

Western blot - Anti-GPA33 antibody (ab231592) at 1 µg/mL

All lanes:

Recombinant rat GPA33 protein

Predicted band size: 36 kDa,53 kDa

false

Western blot - Anti-GPA33 antibody (AB231592)
  • WB

Supplier Data

Western blot - Anti-GPA33 antibody (AB231592)

All lanes:

Western blot - Anti-GPA33 antibody (ab231592) at 1 µg/mL

Lane 1:

Rat large intestine tissue lysate

Lane 2:

Mouse small intestine tissue lysate

Secondary

All lanes:

HRP-linked guinea pig anti-rabbit at 1/2000 dilution

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Recombinant full length protein - Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPA33 also known as Glycoprotein A33 is a cell surface antigen with a molecular mass of approximately 43 kDa. The protein is primarily expressed in the gastrointestinal tract especially in epithelial cells of the colon and small intestine. GPA33 is known for its role in cellular adhesion and maintaining epithelial integrity. It features as a single-pass transmembrane protein hinting at its involvement in cell signaling processes.
Biological function summary

The GPA33 protein plays a role in cell-cell adhesion and is implicated in forming stable cell-community networks. It is associated with the epithelial membrane complexes contributing to the structural integrity vital for epithelial tissue health. GPA33 does not function in isolation but interacts with other cell surface molecules to mediate its effects supporting epithelial tissue resistance and injury repair.

Pathways

The GPA33 antigen engages in signaling pathways important for epithelial cell adhesion and communication. It is involved in the Wnt signaling pathway which is pivotal in colon epithelial homeostasis and tumor suppression. Through this pathway GPA33 interacts with proteins such as β-catenin facilitating signal transduction that governs cell proliferation and differentiation.

GPA33 has strong associations with colorectal cancer and inflammatory bowel disease. Overexpression of GPA33 occurs frequently in colorectal cancer providing a target for therapeutic intervention and diagnostic imaging. GPA33's role in colorectal cancer also links it to proteins like carcinoembryonic antigen (CEA) which are vital in cancer progression and metastasis. Understanding GPA33's involvement in these diseases is important for developing targeted therapies and improving patient outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Glycoprotein A33
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular metabolism 91:102069 PubMed39571901

2024

The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Fangzhen Xia,Ziteng Zhang,Zhen Qian,Xiaoyu Fang,Junxue Wang,Yan Wang,Guoting Sun,Yuefeng Yu,Ninjian Wang,Junke Zhen,Yan Liu,Yingli Lu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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