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Rabbit Polyclonal GPCR G2A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GPR132 conjugated to Keyhole Limpet Haemocyanin.

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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human GPR132 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UNW8
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species

Human

Dilution info

12 µg/mL

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target data

Function

May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.

Alternative names

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Rabbit Polyclonal GPCR G2A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GPR132 conjugated to Keyhole Limpet Haemocyanin.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human GPR132 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UNW8
Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

The receptor contributes to cell signaling by detecting and responding to distinct lipid metabolites. While G2A is not typically part of a large multi-protein complex its activity influences the local cellular environment by altering signaling cascades involved in immune response and inflammation. Research indicates that G2A plays a role in lipid homeostasis and the positioning of immune cells like lymphocytes which are important for maintaining balanced immune activities.

Activity summary

GPCR G2A also known as GPR132 is a G protein-coupled receptor involved in various cellular functions. This receptor has a molecular mass of approximately 43 kDa and is expressed in a wide range of tissues including immune cells endothelial cells and certain types of cancer cells. The expression pattern suggests its involvement in diverse physiological processes. Researchers often refer to it using different names based on the context or geographical studies including G2A alternative and G2A Canada though these mainly reflect differences in study focus rather than the protein itself.

Pathways

GPCR G2A integrates into the lysophosphatidylcholine (LPC) signaling pathway. This pathway is important for regulating immune cell migration and cellular responses to stress. G2A connects closely to downstream signaling molecules like G-proteins indicating its pivotal role in LPC signaling. Moreover it connects functionally with other receptors within the GPCR family facilitating crosstalk by interacting with various signaling molecules and receptors that modulate immune cell activities.

Associated diseases and disorders

G2A has associations with cardiovascular diseases and autoimmune conditions. Its activity influences inflammatory responses which are central to these diseases. The receptor's function in immune regulation creates links with inflammation-related proteins such as chemokines and cytokines further impacting these health conditions. Understanding the role of G2A in these diseases opens opportunities for targeted therapies aiming to modulate its activity particularly in disorders where inflammation plays a significant role.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR G2A antibody (ab116586), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR G2A antibody (ab116586)

    Immunohistochemistry Image of Human Spleen (formalin-fixed, paraffin-embedded) stained with GPCRG2A antibody (ab116586)at 11 μg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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