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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal GPCR G2A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GPR132 conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 12 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.
Probable G-protein coupled receptor 132, G2 accumulation protein, G2A, GPR132
Rabbit Polyclonal GPCR G2A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GPR132 conjugated to Keyhole Limpet Haemocyanin.
Probable G-protein coupled receptor 132, G2 accumulation protein, G2A, GPR132
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
The receptor contributes to cell signaling by detecting and responding to distinct lipid metabolites. While G2A is not typically part of a large multi-protein complex its activity influences the local cellular environment by altering signaling cascades involved in immune response and inflammation. Research indicates that G2A plays a role in lipid homeostasis and the positioning of immune cells like lymphocytes which are important for maintaining balanced immune activities.
GPCR G2A also known as GPR132 is a G protein-coupled receptor involved in various cellular functions. This receptor has a molecular mass of approximately 43 kDa and is expressed in a wide range of tissues including immune cells endothelial cells and certain types of cancer cells. The expression pattern suggests its involvement in diverse physiological processes. Researchers often refer to it using different names based on the context or geographical studies including G2A alternative and G2A Canada though these mainly reflect differences in study focus rather than the protein itself.
GPCR G2A integrates into the lysophosphatidylcholine (LPC) signaling pathway. This pathway is important for regulating immune cell migration and cellular responses to stress. G2A connects closely to downstream signaling molecules like G-proteins indicating its pivotal role in LPC signaling. Moreover it connects functionally with other receptors within the GPCR family facilitating crosstalk by interacting with various signaling molecules and receptors that modulate immune cell activities.
G2A has associations with cardiovascular diseases and autoimmune conditions. Its activity influences inflammatory responses which are central to these diseases. The receptor's function in immune regulation creates links with inflammation-related proteins such as chemokines and cytokines further impacting these health conditions. Understanding the role of G2A in these diseases opens opportunities for targeted therapies aiming to modulate its activity particularly in disorders where inflammation plays a significant role.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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Terms & Conditions.
Immunohistochemistry Image of Human Spleen (formalin-fixed, paraffin-embedded) stained with GPCRG2A antibody (ab116586)at 11 μg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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