Anti-GPCR G2A antibody - Extracellular domain

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GPCR G2A also known as GPR132 is a G protein-coupled receptor involved in various cellular functions. This receptor has a molecular mass of approximately 43 kDa and is expressed in a wide range of tissues including immune cells endothelial cells and certain types of cancer cells. The expression pattern suggests its involvement in diverse physiological processes. Researchers often refer to it using different names based on the context or geographical studies including G2A alternative and G2A Canada though these mainly reflect differences in study focus rather than the protein itself.

Biological function summary

The receptor contributes to cell signaling by detecting and responding to distinct lipid metabolites. While G2A is not typically part of a large multi-protein complex its activity influences the local cellular environment by altering signaling cascades involved in immune response and inflammation. Research indicates that G2A plays a role in lipid homeostasis and the positioning of immune cells like lymphocytes which are important for maintaining balanced immune activities.

Pathways

GPCR G2A integrates into the lysophosphatidylcholine (LPC) signaling pathway. This pathway is important for regulating immune cell migration and cellular responses to stress. G2A connects closely to downstream signaling molecules like G-proteins indicating its pivotal role in LPC signaling. Moreover it connects functionally with other receptors within the GPCR family facilitating crosstalk by interacting with various signaling molecules and receptors that modulate immune cell activities.

Associated diseases and disorders

G2A has associations with cardiovascular diseases and autoimmune conditions. Its activity influences inflammatory responses which are central to these diseases. The receptor's function in immune regulation creates links with inflammation-related proteins such as chemokines and cytokines further impacting these health conditions. Understanding the role of G2A in these diseases opens opportunities for targeted therapies aiming to modulate its activity particularly in disorders where inflammation plays a significant role.