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AB169331

Anti-GPCR GPR1 antibody

4

(1 Review)

|

(5 Publications)

Mouse Polyclonal GPCR GPR1 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CMKLR2.

View Alternative Names

GPR1, CMKLR2, Chemerin-like receptor 2, Chemerin chemokine-like receptor 2, Chemokine-like receptor 2, G-protein coupled receptor 1

1 Images
Western blot - Anti-GPCR GPR1 antibody (AB169331)
  • WB

Unknown

Western blot - Anti-GPCR GPR1 antibody (AB169331)

All lanes:

Western blot - Anti-GPCR GPR1 antibody (ab169331) at 1 µg/mL

Lane 1:

GPCR GPR1-transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected cell lysate at 15 µL

Predicted band size: 41 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CMKLR2.

P46091

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Alternative Products

Primary Antibodies

AB157209

Anti-GPCR GPR1 antibody [EPR11008]

RabMAb|Recombinant

Western blot - Anti-GPCR GPR1 antibody [EPR11008] (AB157209)

  • 0
  • 0
Primary Antibodies

AB188977

Anti-GPCR GPR1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR1 antibody (AB188977)

  • 0
  • 1

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

  • 5
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Primary Antibodies

AB188781

Anti-GPCR GPR85 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR85 antibody - C-terminal (AB188781)

  • 0
  • 0
Primary Antibodies

AB92547

Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker (AB92547)

  • 5
  • 92
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR1 a G protein-coupled receptor (GPCR) is an integral membrane protein that plays a role in cellular signaling. Known alternatively as G protein-coupled receptor 1 its mass is about 41 kDa. GPR1 localizes in the cell membrane primarily expressed in tissues like the brain and kidney. Its function involves interaction with specific ligands leading to the activation of G-proteins and the downstream signaling cascade. This makes it an important player in transmitting extracellular signals to the interior of the cell.
Biological function summary

GPR1 takes part in inflammatory response and metabolism regulation. It does not appear to form part of a larger protein complex functioning independently in the pathways it influences. GPR1's role in attracting immune cells to sites of inflammation is significant as it interacts with chemokines to mediate leucocyte migration. In cellular metabolism GPR1 helps maintain energy balance by modulating pathways linked to energy and nutrient availability.

Pathways

GPR1 interacts with the MAPK signaling pathway and the chemokine-mediated signal transduction. These pathways involve proteins like ERK1/2 and CCR1 which help transmit signals that affect cellular responses such as growth differentiation or immune cell trafficking. GPR1 influences these pathways through ligand-binding leading to a cascade of intracellular events that impact cell function and communication.

GPR1 is associated with inflammation-related diseases and metabolic disorders. For instance its role in inflammation pathways links it to conditions like rheumatoid arthritis. It may also contribute to obesity by affecting energy regulation pathways. The protein demonstrates interaction with other receptors like CCR5 in these diseases which facilitates a better understanding of its involvement in pathological states. Researchers are exploring GPR1 as a potential therapeutic target given its role in these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed : 18165312, PubMed : 27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed : 27716822). Also acts as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).. (Microbial infection) Coreceptor for HIV-1.
See full target information CMKLR2
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cells 12: PubMed37626836

2023

Effect of Vitamin D on Chemerin and Adiponectin Levels in Uterus of Polycystic Ovary Syndrome Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Karolina Pich,Jesika Rajewska,Kinga Kamińska,Marcelina Tchurzyk,Agata Szlaga,Patryk Sambak,Anna Błasiak,Małgorzata Grzesiak,Agnieszka Rak

General and comparative endocrinology 299:113584 PubMed32827511

2020

Adipokines expression profiles in both plasma and peri renal adipose tissue in Large White and Meishan sows: A possible involvement in the fattening and the onset of puberty.

Applications

Unspecified application

Species

Unspecified reactive species

Alix Barbe,Patrycja Kurowska,Ewa Mlyczyńska,Christelle Ramé,Christophe Staub,Eric Venturi,Yvon Billon,Agnieszka Rak,Joëlle Dupont

International journal of molecular sciences 21: PubMed32717877

2020

The In Vitro Effect of Prostaglandin E and F on the Chemerin System in the Porcine Endometrium during Gestation.

Applications

Unspecified application

Species

Unspecified reactive species

Kamil Dobrzyn,Marta Kiezun,Ewa Zaobidna,Katarzyna Kisielewska,Edyta Rytelewska,Marlena Gudelska,Grzegorz Kopij,Kinga Bors,Karolina Szymanska,Barbara Kaminska,Tadeusz Kaminski,Nina Smolinska

Molecular reproduction and development 87:739-762 PubMed32557981

2020

Expression of chemerin and its receptors in the ovaries of prepubertal and mature gilts.

Applications

Unspecified application

Species

Unspecified reactive species

Edyta Rytelewska,Katarzyna Kisielewska,Marta Kiezun,Kamil Dobrzyn,Marlena Gudelska,Agnieszka Rak,Joelle Dupont,Barbara Kaminska,Tadeusz Kaminski,Nina Smolinska

International journal of molecular sciences 20: PubMed31404950

2019

Expression of Chemerin and Its Receptors in the Porcine Hypothalamus and Plasma Chemerin Levels during the Oestrous Cycle and Early Pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Nina Smolinska,Marta Kiezun,Kamil Dobrzyn,Edyta Rytelewska,Katarzyna Kisielewska,Marlena Gudelska,Ewa Zaobidna,Krystyna Bogus-Nowakowska,Joanna Wyrebek,Kinga Bors,Grzegorz Kopij,Barbara Kaminska,Tadeusz Kaminski
View all publications
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Product promise

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