Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Product Insider Program
Be the first to know about our latest product launches - and unlock exclusive offers and discounts.
Rabbit Polyclonal GPCR GPR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR1.
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Bat | Predicted |
Common marmoset | Predicted |
Cow | Predicted |
Gorilla | Predicted |
Monkey | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 23.00000-46.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Cow, Monkey, Gorilla, Common marmoset, Bat | Dilution info - | Notes - |
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (PubMed:18165312). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).(Microbial infection) Coreceptor for HIV-1.
G-protein coupled receptor 1, CMKLR2, GPR1
Rabbit Polyclonal GPCR GPR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR1.
G-protein coupled receptor 1, CMKLR2, GPR1
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
-20°C
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
GPR1 takes part in inflammatory response and metabolism regulation. It does not appear to form part of a larger protein complex functioning independently in the pathways it influences. GPR1's role in attracting immune cells to sites of inflammation is significant as it interacts with chemokines to mediate leucocyte migration. In cellular metabolism GPR1 helps maintain energy balance by modulating pathways linked to energy and nutrient availability.
GPR1 a G protein-coupled receptor (GPCR) is an integral membrane protein that plays a role in cellular signaling. Known alternatively as G protein-coupled receptor 1 its mass is about 41 kDa. GPR1 localizes in the cell membrane primarily expressed in tissues like the brain and kidney. Its function involves interaction with specific ligands leading to the activation of G-proteins and the downstream signaling cascade. This makes it an important player in transmitting extracellular signals to the interior of the cell.
GPR1 interacts with the MAPK signaling pathway and the chemokine-mediated signal transduction. These pathways involve proteins like ERK1/2 and CCR1 which help transmit signals that affect cellular responses such as growth differentiation or immune cell trafficking. GPR1 influences these pathways through ligand-binding leading to a cascade of intracellular events that impact cell function and communication.
GPR1 is associated with inflammation-related diseases and metabolic disorders. For instance its role in inflammation pathways links it to conditions like rheumatoid arthritis. It may also contribute to obesity by affecting energy regulation pathways. The protein demonstrates interaction with other receptors like CCR5 in these diseases which facilitates a better understanding of its involvement in pathological states. Researchers are exploring GPR1 as a potential therapeutic target given its role in these disorders.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue (neurons and glia) labelling GPCR GPR1 with ab150536 at 23µg/ml.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com