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AB157209

Anti-GPCR GPR1 antibody [EPR11008]

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(2 Publications)

Rabbit Recombinant Monoclonal GPCR GPR1 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 2 publications.

View Alternative Names

GPR1, CMKLR2, Chemerin-like receptor 2, Chemerin chemokine-like receptor 2, Chemokine-like receptor 2, G-protein coupled receptor 1

1 Images
Western blot - Anti-GPCR GPR1 antibody [EPR11008] (AB157209)
  • WB

Unknown

Western blot - Anti-GPCR GPR1 antibody [EPR11008] (AB157209)

All lanes:

Western blot - Anti-GPCR GPR1 antibody [EPR11008] (ab157209) at 1/1000 dilution

Lane 1:

C6 cell lysate at 10 µg

Lane 2:

U87-MG cell lysate at 10 µg

Lane 3:

SH-SY5Y cell lysate at 10 µg

Predicted band size: 41 kDa

false

  • Carrier free

    Anti-GPCR GPR1 antibody [EPR11008] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11008

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Species reactivity
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR1 a G protein-coupled receptor (GPCR) is an integral membrane protein that plays a role in cellular signaling. Known alternatively as G protein-coupled receptor 1 its mass is about 41 kDa. GPR1 localizes in the cell membrane primarily expressed in tissues like the brain and kidney. Its function involves interaction with specific ligands leading to the activation of G-proteins and the downstream signaling cascade. This makes it an important player in transmitting extracellular signals to the interior of the cell.
Biological function summary

GPR1 takes part in inflammatory response and metabolism regulation. It does not appear to form part of a larger protein complex functioning independently in the pathways it influences. GPR1's role in attracting immune cells to sites of inflammation is significant as it interacts with chemokines to mediate leucocyte migration. In cellular metabolism GPR1 helps maintain energy balance by modulating pathways linked to energy and nutrient availability.

Pathways

GPR1 interacts with the MAPK signaling pathway and the chemokine-mediated signal transduction. These pathways involve proteins like ERK1/2 and CCR1 which help transmit signals that affect cellular responses such as growth differentiation or immune cell trafficking. GPR1 influences these pathways through ligand-binding leading to a cascade of intracellular events that impact cell function and communication.

GPR1 is associated with inflammation-related diseases and metabolic disorders. For instance its role in inflammation pathways links it to conditions like rheumatoid arthritis. It may also contribute to obesity by affecting energy regulation pathways. The protein demonstrates interaction with other receptors like CCR5 in these diseases which facilitates a better understanding of its involvement in pathological states. Researchers are exploring GPR1 as a potential therapeutic target given its role in these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed : 18165312, PubMed : 27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed : 27716822). Also acts as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).. (Microbial infection) Coreceptor for HIV-1.
See full target information CMKLR2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Brain, behavior, and immunity 70:179-193 PubMed29499303

2018

Chemerin suppresses neuroinflammation and improves neurological recovery via CaMKK2/AMPK/Nrf2 pathway after germinal matrix hemorrhage in neonatal rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yixin Zhang,Ningbo Xu,Yan Ding,Yiting Zhang,Qian Li,Jerry Flores,Mina Haghighiabyaneh,Desislava Doycheva,Jiping Tang,John H Zhang

Oncotarget 8:95135-95151 PubMed29221117

2017

Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability and impairs tumor growth .

Applications

WB

Species

Human

Conny Tümmler,Igor Snapkov,Malin Wickström,Ugo Moens,Linda Ljungblad,Lotta Helena Maria Elfman,Jan-Olof Winberg,Per Kogner,John Inge Johnsen,Baldur Sveinbjørnsson
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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