Anti-GPCR GPR10 antibody - Extracellular domain

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GPR10 also known as the prokineticin receptor 1 is a member of the G-protein-coupled receptor (GPCR) family. The mass of GPR10 is approximately 49 kDa. This receptor is mainly expressed in the central nervous system and the peripheral tissues including the pituitary gland and the pancreas. GPR10 functions by binding to its natural ligand prokineticin which initiates signaling pathways inside the cell through interaction with G proteins.

Biological function summary

GPR10 plays a significant role in modulating neurological and endocrine functions. It does not form part of a complex like some other GPCRs acting independently when activated to regulate cellular responses. GPR10 influences the secretion of various hormones and neuropeptides impacting processes such as energy balance pain modulation and circadian rhythms. The regulation of these processes highlights the critical functional role GPR10 has in the body's homeostasis.

Pathways

GPR10 is involved in the neuropeptide signaling pathway and the energy homeostasis pathway. Within these pathways GPR10 interacts with a variety of proteins that modulate cellular and physiological responses. A notable relationship is with the melanocortin system which also plays a role in energy regulation. By influencing these pathways GPR10 ensures the efficient coordination of signals that affect metabolic and neurological functions.

Associated diseases and disorders

Aberrant GPR10 function relates to some neuropsychological and metabolic conditions such as obesity and anxiety disorders. In obesity the dysregulation of energy balance pathways that involve GPR10 leads to abnormal energy storage and consumption. The serotonin receptor family with which GPR10 shares connection through signaling pathways also highlights its role in mood disorders. These connections make GPR10 a potential target for therapeutic intervention aiming to modulate its activity in relevant disease contexts.