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AB140949

Anti-GPCR GPR10 antibody - Extracellular domain

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(1 Publication)

Rabbit Polyclonal GPCR GPR10 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PRLHR.

View Alternative Names

GPR10, GR3, PRLHR, Prolactin-releasing peptide receptor, PrRP receptor, PrRPR, G-protein coupled receptor 10, hGR3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR10 antibody - Extracellular domain (AB140949)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR10 antibody - Extracellular domain (AB140949)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pituitary (anterior) tissue labelling GPCR GPR10 with ab140949 at 2 µg/ml after heat-induced antigen retrieval.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PRLHR. The exact immunogen used to generate this antibody is proprietary information.

P49683

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR10 also known as the prokineticin receptor 1 is a member of the G-protein-coupled receptor (GPCR) family. The mass of GPR10 is approximately 49 kDa. This receptor is mainly expressed in the central nervous system and the peripheral tissues including the pituitary gland and the pancreas. GPR10 functions by binding to its natural ligand prokineticin which initiates signaling pathways inside the cell through interaction with G proteins.
Biological function summary

GPR10 plays a significant role in modulating neurological and endocrine functions. It does not form part of a complex like some other GPCRs acting independently when activated to regulate cellular responses. GPR10 influences the secretion of various hormones and neuropeptides impacting processes such as energy balance pain modulation and circadian rhythms. The regulation of these processes highlights the critical functional role GPR10 has in the body's homeostasis.

Pathways

GPR10 is involved in the neuropeptide signaling pathway and the energy homeostasis pathway. Within these pathways GPR10 interacts with a variety of proteins that modulate cellular and physiological responses. A notable relationship is with the melanocortin system which also plays a role in energy regulation. By influencing these pathways GPR10 ensures the efficient coordination of signals that affect metabolic and neurological functions.

Aberrant GPR10 function relates to some neuropsychological and metabolic conditions such as obesity and anxiety disorders. In obesity the dysregulation of energy balance pathways that involve GPR10 leads to abnormal energy storage and consumption. The serotonin receptor family with which GPR10 shares connection through signaling pathways also highlights its role in mood disorders. These connections make GPR10 a potential target for therapeutic intervention aiming to modulate its activity in relevant disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
See full target information PRLHR
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular biosciences 8:794326 PubMed35155566

2022

Metastatic Immune-Related Genes for Affecting Prognosis and Immune Response in Renal Clear Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Si Sun,Weipu Mao,Lilin Wan,Kehao Pan,Liting Deng,Lei Zhang,Guangyuan Zhang,Ming Chen
View all publications
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Product promise

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