Anti-GPCR GPR103 antibody - N-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

G protein-coupled receptor 103 (GPR103) also known as AQ27 is a protein encoded by the QRFPR gene. It is part of the GPCR family characterized by having seven transmembrane domains. This protein has a molecular mass of approximately 45 kDa. GPR103 is commonly expressed in the brain particularly found in the hypothalamus and brainstem. Some expression is also considered in peripheral tissues like adipose tissue. It plays an essential role in various signaling mechanisms triggered by its endogenous ligand 26RFa or QRFP.

Biological function summary

GPR103 influences energy balance and metabolism by modulating the release of hormones involved in food intake and energy expenditure. It interacts with neuropeptides and influences several bodily functions including control of blood pressure and reproductive hormone regulation. GPR103 does not function in isolation; it often acts together with other receptors and proteins to execute biological signals impacting physiological responses.

Pathways

GPR103 participates in neuropeptide signaling pathways which impact feeding behavior and energy homeostasis. It is directly associated with pathways such as the MAPK/ERK signaling pathway connecting it to the regulation of cell proliferation and differentiation. In these processes GPR103 interacts with related proteins like GPR39 and GPR40 influencing various physiological outcomes.

Associated diseases and disorders

Studies associate GPR103 with obesity and hypertension. Dysregulation of this receptor can affect appetite control and energy homeostasis contributing to obesity. It also plays a role in cardiovascular diseases by influencing blood pressure levels. Through its involvement in these conditions GPR103 interacts with proteins like leptin which is significant in the regulation of body weight and energy balance. Researchers continue to explore the therapeutic potential of targeting GPR103 in relevant diseases.