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AB150547

Anti-GPCR GPR110 antibody

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(2 Publications)

Rabbit Polyclonal GPCR GPR110 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRF1.

View Alternative Names

GPR110, PGR19, ADGRF1, Adhesion G-protein coupled receptor F1, G protein-coupled receptor 110, G protein-coupled receptor KPG_012

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR110 antibody (AB150547)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR110 antibody (AB150547)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue (renal tubules) labeling GPCR GPR110 with ab150547 at 11µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ADGRF1. The exact immunogen used to generate this antibody is proprietary information.

Q5T601

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

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Secondary Antibodies

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Primary Antibodies

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "11 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

G protein-coupled receptor 110 or GPR110 also known as ADGRF1 plays a significant role in cell signaling mechanisms. This receptor is part of the adhesion GPCR family and exhibits a large extracellular domain. GPR110 has a molecular mass that may vary based on its glycosylation patterns but it typically approaches 115 kDa. Researchers have identified its expression in various tissues with higher levels noted in the lungs brain and testes. Its unique structure allows it to interact with a variety of ligands mediating diverse cellular responses.
Biological function summary

GPR110 engages in key cellular processes that influence immune responses and cellular communication. This receptor is not part of any known major protein complex but it often pairs intracellularly with G proteins to transmit signals. GPR110 mediates cell adhesion and migration important for maintaining tissue architecture and immune cell trafficking. It may impact early developmental stages due to its significant involvement in signaling pathways linked to cell growth and differentiation.

Pathways

GPR110 integrates into the Wnt signaling pathway and the PI3K/Akt pathway both of which are central to cell growth and survival. Its interaction with the Wnt pathway links it to essential regulatory proteins like beta-catenin influencing gene transcription and cell fate decisions. The PI3K/Akt pathway associates GPR110 with proteins that control apoptosis and cell proliferation. These connections highlight its regulatory roles in cellular dynamics indicating its contributions to these essential pathways.

GPR110 has links to lung cancer and neurological disorders such as Alzheimer's disease. In lung cancer overexpression or mutations of GPR110 may lead to aberrant cell signaling contributing to uncontrolled cell proliferation and tumor growth. In Alzheimer's disease abnormal GPR110 activity might influence neuronal signaling and cell survival with possible interactions involving the Alzheimer's-related protein beta-amyloid. Understanding these connections helps researchers explore potential therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Adhesion G-protein coupled receptor (aGPCR) for N-docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain (PubMed : 27759003, PubMed : 32144388). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 35418679, PubMed : 36127364, PubMed : 37120430). ADGRF1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed : 35418679). Also able to couple to G(q), G(i) and G(12)/G(13) G proteins; additional evidence is however required to confirm this result in vivo (PubMed : 36127364, PubMed : 37120430). Involved in the development of neurons and cognitive function (By similarity). In liver, involved in fat accumulation (By similarity).
See full target information ADGRF1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Annals of translational medicine 8:745 PubMed32647670

2020

The role of GPR110 in lung cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Benting Ma,Junjie Zhu,Jieakesu Su,Feng Pan,Yuan Ji,Lijuan Luan,Jie Huang,Yingyong Hou

Medical science monitor : international medical jo 24:5216-5224 PubMed30052620

2018

Clinical Significance of G Protein-Coupled Receptor 110 (GPR110) as a Novel Prognostic Biomarker in Osteosarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiqiang Liu,Guorong Zhang,Changlei Zhao,Juming Li
View all publications
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Product promise

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