Anti-GPCR GPR116 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GPCR GPR116 also known as adhesion G protein-coupled receptor F5 is a receptor protein that belongs to the large family of adhesion GPCRs. The GPR116 protein has an approximate mass of 140 kDa. It plays a role in regulating G protein signaling and interacts with other cellular proteins through its extracellular and intracellular domains. GPR116 is expressed in multiple tissues with high expression levels noted in endothelial cells lungs and adipose tissue.

Biological function summary

This receptor is involved in important processes like maintaining pulmonary surfactant homeostasis and regulating vascular integrity. GPR116 does not function alone but as part of larger receptor complexes interacting with various other proteins and molecules at the cellular membrane. Its activity influences the balance of signals within the cell impacting cellular responses and activities.

Pathways

GPR116 is an important component in the surfactant and vascular maintenance pathways. It is associated with the phosphatidylinositol signaling system and can influence phospholipase C activity. GPR116 also interacts with other proteins like thrombin which assists in mediating inflammatory responses via G protein-coupled signal transduction.

Associated diseases and disorders

Dysfunction of GPR116 has implications in respiratory conditions like pulmonary alveolar proteinosis and cardiovascular diseases such as hypertension. In these disease contexts GPR116's relationship with proteins like surfactant protein A and B shows its role in regulating respiratory and cardiovascular conditions. Understanding these interactions might offer insights into targeting GPR116 for therapeutic interventions.