Anti-GPCR GPR119 antibody [Gipg013]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GPR119 also known as Glucose-dependent insulinotropic receptor is a G protein-coupled receptor (GPCR) that plays an essential role in metabolic regulation. With a mass of approximately 51 kDa it is expressed mainly in pancreatic beta cells and intestinal enteroendocrine cells. This receptor senses dietary lipids and promotes insulin secretion in response to meals. It also couples with G proteins to initiate intracellular signaling cascades important for energy homeostasis.

Biological function summary

GPR119 functions as a sensor of lipid-derived molecules often acting as an aryl agonist receptor. It is not part of a larger complex but can activate a series of downstream pathways upon ligand binding. When activated by endogenous and synthetic agonists GPR119 stimulates the release of incretin hormones such as GLP-1 and GIP. This hormone release enhances insulin response and promotes optimal glycemic control essential in maintaining blood glucose levels.

Pathways

GPR119 signaling pathway is integral in glucose metabolism and energy balance. It links to both the incretin hormone signaling pathway and the insulin signaling pathway. Upon activation it influences the levels of cAMP an important secondary messenger that modulates several downstream effects including the regulation of the insulin receptor. GPR119 interacts with other proteins such as adenylate cyclase affecting insulin secretion and lipid metabolism.

Associated diseases and disorders

GPR119 has significant relevance to type 2 diabetes and obesity. Its role in glucose homeostasis and energy balance makes it a potential therapeutic target for these conditions. Researchers examine GPR119 agonists as possible treatments for enhancing insulin secretion and controlling body weight. The receptor is linked to related pathways integrating multiple metabolic signals including those mediated by GLP-1 an important hormone involved in energy regulation and glycemic control.