Anti-GPCR GPR120 antibody

Target data

G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways (PubMed : 26873857, PubMed : 27852822). LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs) (PubMed : 26873857, PubMed : 27852822). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed : 26873857, PubMed : 27852822). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation (PubMed : 17250804, PubMed : 22343897, PubMed : 27853148, PubMed : 29343498, PubMed : 31761534). Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry (PubMed : 31761534). Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone (PubMed : 27853148, PubMed : 29343498). Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue (PubMed : 27853148, PubMed : 29343498). Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration (PubMed : 29343498). Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass (PubMed : 29343498). Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins (PubMed : 26365922). In response to dietary fats regulates hormone secretion and appetite (PubMed : 15619630, PubMed : 24222669, PubMed : 24663807, PubMed : 24742677, PubMed : 25535828). Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels (PubMed : 15619630, PubMed : 24742677, PubMed : 25535828). Negatively regulates glucose-induced SST secretion in pancreatic delta cells (PubMed : 24663807). Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone (PubMed : 24222669). In taste buds, contributes to sensing of dietary fatty acids by the gustatory system (PubMed : 20573884). During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (PubMed : 20813258). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (By similarity). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (PubMed : 20813258). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of pro-inflammatory cytokine release (By similarity). Mediates LCFAs anti-apoptotic effects (PubMed : 15774482).