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AB67280

Anti-GPCR GPR124 antibody

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(1 Publication)

Rabbit Polyclonal GPCR GPR124 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ADGRA2.

View Alternative Names

GPR124, KIAA1531, TEM5, ADGRA2, Adhesion G protein-coupled receptor A2, G-protein coupled receptor 124, Tumor endothelial marker 5

1 Images
Western blot - Anti-GPCR GPR124 antibody (AB67280)
  • WB

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Western blot - Anti-GPCR GPR124 antibody (AB67280)

Lane 1:

Western blot - Anti-GPCR GPR124 antibody (ab67280) at 2 µg/mL

Lane 2:

Western blot - Anti-GPCR GPR124 antibody (ab67280) at 4 µg/mL

All lanes:

Rat kidney tissue lysate at 15 µg

Predicted band size: 143 kDa

Observed band size: 176 kDa,180 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ADGRA2. The exact immunogen used to generate this antibody is proprietary information.

Q96PE1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The GPCR GPR124 also known as Tem5 is a member of the G protein-coupled receptor family. This receptor has a molecular mass of approximately 153 kDa. GPR124 localizes mainly in the central nervous system and also shows expression in endothelial cells of blood vessels. This protein functions as a receptor involved in cellular signaling through its interaction with other proteins and extracellular molecules.
Biological function summary

The receptor plays a significant role in vascular development and angiogenesis. GPR124 forms part of a larger protein complex and contributes to maintaining blood-brain barrier integrity. It acts through its ability to bind to ligands influencing cellular processes that are essential for the proper formation and functioning of blood vessels.

Pathways

Interactions in which GPR124 participates have a notable impact on the Wnt signaling pathway. It collaborates with other proteins such as Frizzled receptors and Dishevelled proteins within this pathway. This interaction influences cellular events like proliferation and differentiation important for proper embryonic development and maintenance of adult tissue homeostasis.

Studies link GPR124 to brain vascular malformations and certain types of cancer. Alterations in its expression or function can lead to cerebral cavernous malformations a condition characterized by irregular blood vessel formation in the brain. Additionally GPR124's interplay with VEGFA an important protein in angiogenesis suggests its involvement in tumorigenesis processes that rely on blood vessel growth for tumor survival and expansion.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed : 28289266, PubMed : 30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling : required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed : 30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed : 30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed : 16982628).
See full target information ADGRA2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 16:2143-2150 PubMed30008912

2018

β-elemene enhances anticancer bone neoplasms efficacy of paclitaxel through regulation of GPR124 in bone neoplasms cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zongze Wang,Ying Li,Fengxin Zhou,Zhe Piao,Jian Hao
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Product promise

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