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AB117092

Anti-GPCR GPR126 antibody

4

(1 Review)

|

(2 Publications)

Rabbit Polyclonal GPCR GPR126 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRG6 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

DREG, GPR126, VIGR, ADGRG6, Adhesion G-protein coupled receptor G6, Developmentally regulated G-protein-coupled receptor, G-protein coupled receptor 126, Vascular inducible G protein-coupled receptor

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR126 antibody (AB117092)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR126 antibody (AB117092)

ab117092 at 10 μg/ml staining GPCR GPR126 in Formalin-Fixed, Paraffin-Embedded Human Liver tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR126 antibody (AB117092)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR126 antibody (AB117092)

ab117092 at 10 μg/ml staining GPCR GPR126 in Formalin-Fixed, Paraffin-Embedded Human Prostate tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ADGRG6 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q86SQ4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p>Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.</p> Perform enzymatic antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR126 also known as ADGRG6 is a member of the adhesion G protein-coupled receptors (GPCRs) family. This protein is involved in various important cellular processes through its mechanical function. It acts as an important regulator of myelination in the peripheral nervous system and influences the development of Schwann cells. GPR126 plays a critical role in signal transmission across cell membranes via its involvement in signal transduction processes. This receptor has a mass of approximately 150 kDa and is widely expressed in various tissues including the nervous system heart and cartilage.
Biological function summary

GPR126 is critical for several developmental processes including myelination and cartilage formation. GPR126 functions within a protein complex that includes G proteins which are responsible for transmitting signals from outside the cell to its interior. This interplay allows Schwann cell differentiation and proliferation contributing to proper peripheral nerve development. Additionally GPR126 facilitates chondrogenesis supporting cartilage development by modulating cell signaling pathways relevant to skeletal growth.

Pathways

GPR126 is involved in the cAMP signaling pathway. This pathway is essential for various cellular functions such as cell growth and differentiation. GPR126 interacts with the adenylyl cyclase enzyme and G protein alpha subunits facilitating the conversion of ATP to cyclic AMP an important secondary messenger. Another significant pathway includes its participation in the Wnt signaling pathway which influences cell fate determination and proliferation. In these pathways GPR126's interactions with proteins like G protein-coupled receptors ensure proper cellular responses to diverse signals.

GPR126 has links to peripheral demyelinating neuropathies such as Charcot-Marie-Tooth disease type 1E characterized by Schwann cell abnormalities. Mutations in GPR126 affect its signaling capacity leading to impaired nerve function. Additionally GPR126 associates with idiopathic scoliosis where anomalies in musculoskeletal development occur. Altered expression or function of related proteins such as those involved in cartilage maintenance may also contribute to these disorders highlighting the importance of GPR126 in maintaining normal physiological processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP) (PubMed : 35394864, PubMed : 39884271). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 24227709, PubMed : 35394864). ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed : 24227709, PubMed : 35394864). Also able to couple to G(q) G proteins (PubMed : 24227709). Involved in myelination of the peripheral nervous system : required for differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed : 24227709). Also acts as a regulator of body length and bone mass (PubMed : 18391950). Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1 (By similarity).
See full target information ADGRG6
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

eLife 10: PubMed34318745

2021

An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaoyang Liu,Amro A Hussien,Yunjia Wang,Terry Heckmann,Roberto Gonzalez,Courtney M Karner,Jess G Snedeker,Ryan S Gray

Nature communications 10:720 PubMed30755618

2019

Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Song Wu,Tong Ou,Nianzeng Xing,Jiang Lu,Shengqing Wan,Changxi Wang,Xi Zhang,Feiya Yang,Yi Huang,Zhiming Cai
View all publications
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Product promise

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