Rabbit Polyclonal GPCR GPR146 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human GPR146 aa 150-300.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol (glycerin, glycerine), 49.99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human GPR146 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q96CH1
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Monkey | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/3000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Monkey | Dilution info - | Notes - |
Associated Products
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2 products for Alternative Product
Target data
Function
G-protein coupled receptor required for the regulation of plasma cholesterol levels (PubMed:31778654, PubMed:38503280). Receptor for cholesin, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed:38503280).
Alternative names
PGR8, GPR146, Probable G-protein coupled receptor 146, G-protein coupled receptor PGR8
Recommended products
Rabbit Polyclonal GPCR GPR146 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human GPR146 aa 150-300.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol (glycerin, glycerine), 49.99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human GPR146 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q96CH1
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
G protein-coupled receptor 146 commonly known as GPCR GPR146 is a member of the extensive GPCR family involved in cell signaling. It weighs approximately 42 kDa. GPR146 is located on the cell membrane mainly expressed in the brain and heart tissues. This protein like other GPCRs works by activating intracellular signal transduction pathways in response to extracellular signals.
- Biological function summary
GPCR GPR146 binds with specific ligands initiating a signaling cascade that affects cellular responses. While no solid evidence indicates that GPR146 forms part of a complex it seems to interact with G proteins. This interaction stimulates secondary messenger pathways which can modulate various physiological processes.
- Pathways
GPR146 is implicated in the G protein signaling pathway influencing processes like neurotransmission and cardiovascular regulation. It maintains connections with other proteins in these pathways such as G proteins and adenylate cyclases which are important for propagating signal transduction events within the cell ultimately influencing cellular responses.
- Associated diseases and disorders
GPCR GPR146 has been linked to atherosclerosis and cardiovascular diseases. Alterations in GPCR GPR146 could disrupt normal signal transduction contributing to these conditions. It shows relations to other proteins involved in these disorders such as LDL receptors which highlights its significance in lipid metabolism and cardiovascular health.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-GPCR GPR146 antibody (ab151626)
10% SDS PAGE
All lanes: Western blot - Anti-GPCR GPR146 antibody (ab151626) at 1/1000 dilution
All lanes: H1299 whole cell lysate at 30 µg
Predicted band size: 37 kDa
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