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Rabbit Polyclonal GPCR GPR146 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human GPR146 aa 150-300.

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Images

Western blot - Anti-GPCR GPR146 antibody (AB151626), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol (glycerin, glycerine), 49.99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human GPR146 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q96CH1

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Monkey
Predicted

Tested
Tested

Species

Human

Dilution info

1/500 - 1/3000

Notes

-

Predicted
Predicted

Species

Monkey

Dilution info

-

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

G-protein coupled receptor required for the regulation of plasma cholesterol levels (PubMed:31778654, PubMed:38503280). Receptor for cholesin, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed:38503280).

Alternative names

PGR8, GPR146, Probable G-protein coupled receptor 146, G-protein coupled receptor PGR8

Recommended products

Rabbit Polyclonal GPCR GPR146 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human GPR146 aa 150-300.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human GPR146 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q96CH1
Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

G protein-coupled receptor 146 commonly known as GPCR GPR146 is a member of the extensive GPCR family involved in cell signaling. It weighs approximately 42 kDa. GPR146 is located on the cell membrane mainly expressed in the brain and heart tissues. This protein like other GPCRs works by activating intracellular signal transduction pathways in response to extracellular signals.

Biological function summary

GPCR GPR146 binds with specific ligands initiating a signaling cascade that affects cellular responses. While no solid evidence indicates that GPR146 forms part of a complex it seems to interact with G proteins. This interaction stimulates secondary messenger pathways which can modulate various physiological processes.

Pathways

GPR146 is implicated in the G protein signaling pathway influencing processes like neurotransmission and cardiovascular regulation. It maintains connections with other proteins in these pathways such as G proteins and adenylate cyclases which are important for propagating signal transduction events within the cell ultimately influencing cellular responses.

Associated diseases and disorders

GPCR GPR146 has been linked to atherosclerosis and cardiovascular diseases. Alterations in GPCR GPR146 could disrupt normal signal transduction contributing to these conditions. It shows relations to other proteins involved in these disorders such as LDL receptors which highlights its significance in lipid metabolism and cardiovascular health.

Product promise

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1 product image

  • Western blot - Anti-GPCR GPR146 antibody (ab151626), expandable thumbnail

    Western blot - Anti-GPCR GPR146 antibody (ab151626)

    10% SDS PAGE

    All lanes: Western blot - Anti-GPCR GPR146 antibody (ab151626) at 1/1000 dilution

    All lanes: H1299 whole cell lysate at 30 µg

    Predicted band size: 37 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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