AB188938

Anti-GPCR GPR15 antibody - Extracellular domain

Name: Anti-GPCR GPR15 antibody - Extracellular domain (ab188938) | Abcam
Brand: Abcam Limited
SKU: AB188938
Price: 630 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal GPCR GPR15 antibody. Extracellular domain. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR15.

View Alternative Names

G-protein coupled receptor 15, Brother of Bonzo, BoB, GPR15

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR15 antibody - Extracellular domain (AB188938)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR15 antibody - Extracellular domain (AB188938)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver tissue labeling GPCR GPR15 with ab188938 at 10 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR15 antibody - Extracellular domain (AB188938)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling GPCR GPR15 with ab188938 at 10 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GPR15. The exact immunogen used to generate this antibody is proprietary information.

P49685

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p>Antigen retrieval requires Proteinase K treatment.</p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The G-protein coupled receptor GPR15 also known as BOB is a seven-transmembrane domain receptor belonging to the GPCR superfamily. While its exact molecular mass varies slightly between species it generally hovers around 40–45 kDa. GPR15 is mainly expressed in the gastrointestinal tract particularly the colon as well as in immune cells like T-cells. The receptor is involved in binding and signal transduction which triggers downstream signaling pathways. Researchers often use GPCR antibodies to study interactions involving GPR15 which holds significance in understanding its mechanical functionality.

Biological function summary

GPR15 functions as a mediator for immune and inflammatory responses. It plays a role in T-cell trafficking to mucosal tissues where it helps manage immune surveillance and response. Its biological function does not seem to involve participation in large protein complexes. The receptor interacts with its ligand GPR15L facilitating signaling cascades that impact immune cell behavior. This interaction is essential for processes like maintaining intestinal homeostasis and could have broader implications in immune system regulation.

Pathways

GPR15 is closely associated with the chemokine-mediated signaling pathways. It modulates the migration and adhesion of immune cells which are critical for maintaining mucosal immunity. GPR15L serves as its ligand in these pathways which highlights their regulatory role in immune responses. GPR15 also intersects with inflammatory cytokine signaling highlighting its involvement in pathways that direct inflammatory responses and immune cell homeostasis in the gut environment.

GPR15 has been linked notably to conditions such as inflammatory bowel disease (IBD) and certain types of cancer particularly colorectal cancer. In IBD GPR15-mediated cell migration can exacerbate inflammatory responses in the intestinal lining. The receptor's overexpression has been observed in colorectal cancer potentially contributing to tumor progression through similar immune modulation pathways. By regulating immune cell traffic GPR15 connects with other proteins involved in disease pathways potentially offering targets for therapeutic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

See full target information GPR15

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 7:692 PubMed28386128

2017

G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin.

Applications

ICC

Species

Unspecified reactive species

Bin Pan,Xiangmin Wang,Chie Nishioka,Goichi Honda,Akihito Yokoyama,Lingyu Zeng,Kailin Xu,Takayuki Ikezoe

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GPCR GPR15 antibody - Extracellular domain

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR15 antibody - Extracellular domain (AB188938)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR15 antibody - Extracellular domain (AB188938)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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