Anti-GPCR GPR18 antibody [EPR12359]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GPR18 also known as N-arachidonyl glycine receptor is a G protein-coupled receptor (GPCR) found in various human tissues. It has an approximate mass of 40 kDa. This receptor is expressed most notably in immune cells including lymphocytes and macrophages as well as in the spleen and thymus. In addition to immune tissues GPR18 is also present in the heart brain and gastrointestinal system.

Biological function summary

This receptor plays a role in cellular signaling as part of the cardiovascular and immune system regulation. GPR18 binds specific ligands such as N-arachidonoyl glycine facilitating intracellular communication and response to environmental changes. It does not function alone but integrates into GPCR complexes acting in concert with other receptors to regulate physiological functions like inflammation and cell migration.

Pathways

The involvement of GPR18 in the endocannabinoid signaling and in the immune system makes it an essential player. It interfaces significantly with the endocannabinoid system influencing pathways like the calcium signaling pathway and possibly the MAPK signaling pathway. GPR18 interacts with proteins such as CB2 (cannabinoid receptor 2) to modulate immune responses inflammation and other critical cellular processes.

Associated diseases and disorders

GPR18 is associated with conditions like inflammation and cardiovascular diseases. Changes in its expression or function can contribute to the development of these health issues. The receptor's interaction with proteins like CB2 becomes evident in these contexts where it may modulate disease progression and provide potential therapeutic targets for treating inflammation-related disorders or heart diseases.