Rabbit Polyclonal GPCR GPR32 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR32 conjugated to Keyhole Limpet Haemocyanin.
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- British journal of pharmacology 175:1100-11082018Resolvin E1, resolvin D1 and resolvin D2 inhibit constriction of rat thoracic aorta and human pulmonary artery induced by the thromboxane mimetic U46619.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMelanie Jannaway et. al.PubMed 29352769
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.7
Preservative: 0.1% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human GPR32 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link O75388
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes - |
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2 products for Alternative Product
Target data
Function
G-protein coupled receptor that binds to several ligands including resolvin D1 (RvD1) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. In macrophages, enhances the RvD1-stimulated phagocytic and clearance functions (PubMed:20080636). Macrophages migrate less toward different chemoattractant stimuli but phagocytose more microbial particles (PubMed:26969756). Prevents the increase in Ca(2+) and activation of ERK1/2 used by histamine and its H1 receptor subtype to induce goblet cell secretion by activating PKC and GRK2 to counter-regulate the histamine receptor (PubMed:23462912).
Alternative names
Probable G-protein coupled receptor 32, GPR32
Recommended products
Rabbit Polyclonal GPCR GPR32 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR32 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.7
Preservative: 0.1% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human GPR32 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link O75388
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
G protein-coupled receptor 32 (GPR32) also known as GPR32 is a member of the G protein-coupled receptors (GPCRs) family characterized by its seven-transmembrane domain structure. The molecular mass of GPR32 is approximately 40 kDa. Researchers typically find GPR32 expression in human tissues such as lung and heart. The receptor interacts with specific ligands activating intracellular signaling pathways that lead to various cellular responses.
- Biological function summary
GPR32 plays a role in the immune system regulation and inflammation resolution. It partners with ligand molecules like certain specialized pro-resolving mediators (SPMs) to facilitate anti-inflammatory responses. Scientists study GPR32 as part of the broader network of GPCRs known for their involvement in transmitting signals from the extracellular environment into the cell. By influencing resolution pathways GPR32 helps maintain tissue homeostasis.
- Pathways
GPR32 significantly influences the resolution phase of inflammation and integrates into the SPM signaling pathway. It interacts with other proteins such as the ALX/FPR2 receptor which is also known to mediate anti-inflammatory actions. Through these interactions GPR32 contributes to orchestrating inflammatory pathway modulation a critical process for balancing immune responses and promoting tissue repair.
- Associated diseases and disorders
GPR32 has a reported relation with inflammatory conditions and cardiovascular diseases. Researchers have studied its role in chronic inflammation where disrupted regulation might contribute to pathological inflammation persistence. GPR32's involvement in cardiovascular diseases links it to the regulation of blood pressure and vascular inflammation with potential interactions seen with proteins such as NADPH oxidase known to affect oxidative stress within these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR32 antibody (ab61429)
ab61429, at 10μg/ml, staining human GPR32 in brain cerebellum, using Immunohistochemistry, Formalin/PFA fixed Paraffin embedded tissue.
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