AB169455

Anti-GPCR GPR34 antibody

Name: Anti-GPCR GPR34 antibody (ab169455) | Abcam
Brand: Abcam Limited
SKU: AB169455
Price: 535 USD
Availability: InStock

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(1 Publication)

Mouse Polyclonal GPCR GPR34 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Probable G-protein coupled receptor 34.

View Alternative Names

Probable G-protein coupled receptor 34, GPR34

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR34 antibody (AB169455)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR34 antibody (AB169455)

Immunofluorescent analysis of permeabilized 293 cells labeling GPCR GPR3 with ab169455 at 1μg/ml.

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Western blot - Anti-GPCR GPR34 antibody (AB169455)

All lanes:

Western blot - Anti-GPCR GPR34 antibody (ab169455) at 1 µg/mL

Lane 1:

GPCR GPR34 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 44 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Probable G-protein coupled receptor 34.

Q9UPC5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR34 also known as G-protein coupled receptor 34 is a member of the GPCR family. This receptor has a mass of approximately 44-48 kDa. It localizes mainly to cell membranes due to its seven transmembrane domains characteristic of GPCRs. GPR34 expression has been widely observed in the immune system particularly in immune cells such as macrophages and dendritic cells but it also appears in tissues like the spleen and brain. This suggests its involvement in key physiological processes.

Biological function summary

GPR34 plays a role in the regulation of immune responses and potential modulation of inflammation. It does not explicitly belong to any known receptor complex but works individually to transduce signals from extracellular to intracellular environments. This receptor can influence the behavior of cells by affecting cytokine production and trafficking of immune cells bringing about changes in immune system activity.

Pathways

GPR34 is involved in signaling cascades that impact the phosphatidylinositol signaling system. This pathway is important for several cellular processes including growth metabolism and cell survival. GPR34 shares functional similarities with other GPCRs involved in similar pathways such as GPR18 which also plays roles in immune function modulation. These pathways highlight the importance of GPR34 in maintaining immune homeostasis and offering a platform for potential therapeutic targeting.

GPR34 has been linked to inflammatory diseases and is suspected to contribute to conditions like asthma and rheumatoid arthritis. Its expression pattern and signaling pathways suggest a role in the development and progression of these disorders. GPR34 modulation can impact inflammatory cytokines and chemokine production. Scientists have studied GPR34 in relation to diseases to explore its potential as a therapeutic target. Additionally its interactions with proteins like other GPCRs or inflammatory mediators could provide further insight into disease mechanisms and possible intervention points.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed : 16460680). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity).

See full target information Probable G-protein coupled receptor 34

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Science advances 5:eaau6328 PubMed30820451

2019

Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance.

Applications

Unspecified application

Species

Unspecified reactive species

Rui-Yuan Pan,Jun Ma,Xiang-Xi Kong,Xiao-Feng Wang,Shuo-Shuo Li,Xiao-Long Qi,Yu-Han Yan,Jinbo Cheng,Qingsong Liu,Wanzhu Jin,Chang-Heng Tan,Zengqiang Yuan

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GPCR GPR34 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR34 antibody (AB169455)

Western blot - Anti-GPCR GPR34 antibody (AB169455)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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