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Rabbit Recombinant Monoclonal GPCR GPR37 antibody. Suitable for WB and reacts with Rat samples. Immunogen corresponding to Synthetic Peptide within Human Prosaposin receptor GPR37.

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Images

Western blot - Anti-GPCR GPR37 Antibody [S02-9I6] (AB317386), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • Synthetic Peptide within Human Prosaposin receptor GPR37. Database link O15354

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Predicted
Rat
Tested

Tested
Tested

Species
Rat
Dilution info
1/1000
Notes

-

Predicted
Predicted

Species
Human
Dilution info
-
Notes

-

Target data

Function

G-protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (By similarity). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination. Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway. Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination. Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti-inflammatory profile, and thus helps to reverse inflammatory pain. In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection. Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (By similarity). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway (By similarity).

Alternative names

Recommended products

Rabbit Recombinant Monoclonal GPCR GPR37 antibody. Suitable for WB and reacts with Rat samples. Immunogen corresponding to Synthetic Peptide within Human Prosaposin receptor GPR37.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • Synthetic Peptide within Human Prosaposin receptor GPR37. Database link O15354
Clone number
S02-9I6
Purification technique
Affinity purification
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Western blot - Anti-GPCR GPR37 Antibody [S02-9I6] (ab317386), expandable thumbnail

    Western blot - Anti-GPCR GPR37 Antibody [S02-9I6] (ab317386)

    All lanes: Western blot - Anti-GPCR GPR37 Antibody [S02-9I6] (ab317386) at 1/1000 dilution

    All lanes: rat brain lysate

    Predicted band size: 67 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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