Rabbit Polyclonal GPCR GPR55 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human GPR55.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol (glycerin, glycerine), 49.99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human GPR55. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y2T6
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes - |
Associated Products
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Target data
Function
G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation (PubMed:36142844). In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation (PubMed:37544935).
Alternative names
G-protein coupled receptor 55, GPR55
Recommended products
Rabbit Polyclonal GPCR GPR55 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human GPR55.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol (glycerin, glycerine), 49.99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human GPR55. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y2T6
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The GPR55 receptor also known as G protein-coupled receptor 55 or GPR-55 is a member of the G-protein-coupled receptor (GPCR) family. GPR55 is involved mechanically in cell signaling by interacting with ligands to activate intracellular signal transduction pathways. It has a molecular mass of approximately 37 kDa. This receptor is widely distributed in tissues including the brain spleen and gastrointestinal tract which supports its involvement in various physiological processes.
- Biological function summary
GPR55 influences numerous functions such as modulation of neurotransmitter release and immune responses. Although not part of a larger receptor complex it acts independently as a signaling entity. GPR55 is involved in the regulation of blood pressure potentially influencing cardiovascular health. Its expression and activity in the central nervous system suggest roles in nervous system signaling and regulation.
- Pathways
GPR55 integrates into the cannabinoid signaling pathway and can impact phosphatidylinositol-45-bisphosphate 3-kinase (PI3K) pathway. GPR55 interacts closely with other cannabinoid receptors like CB1 and CB2 although they functionally differ. This receptor's involvement provides flexibility in the signaling networks important for maintaining homeostasis and cellular responses to external stimuli.
- Associated diseases and disorders
GPR55 has associations with cancer and inflammation. Its signaling interference may contribute to tumor growth and could alter inflammatory responses. The receptor shares pathogenetic pathways with proteins such as CB1 and PI3K both of which influence oncogenic and inflammatory mechanisms. Understanding these interactions is essential for targeting GPR55 in therapeutic development for related diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR55 antibody - C-terminal (ab228355)
Paraffin-embedded human prostate tissue stained for GPCR GPR55 using ab228355 at 1/100 dilution in immunohistochemical analysis.
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